6-(ethoxycarbonyl)-3-(2-(4-chlorophenyl)thiazol-5-yl)-5-oxohexanoic acid

Base Information

• Chemical Name: 6-(ethoxycarbonyl)-3-(2-(4-chlorophenyl)thiazol-5-yl)-5-oxohexanoic acid
• CAS No.: 721920-85-0
• Molecular Formula: C₁₈H₁₈ClNO₅S
• Molecular Weight: 395.864

Synonyms:6-(ethoxycarbonyl)-3-(2-(4-chlorophenyl)thiazol-5-yl)-5-oxohexanoic acid

Chemical Property of 6-(ethoxycarbonyl)-3-(2-(4-chlorophenyl)thiazol-5-yl)-5-oxohexanoic acid

Chemical Property:

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Technology Process of 6-(ethoxycarbonyl)-3-(2-(4-chlorophenyl)thiazol-5-yl)-5-oxohexanoic acid

There total 2 articles about 6-(ethoxycarbonyl)-3-(2-(4-chlorophenyl)thiazol-5-yl)-5-oxohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[2-(4-chlorophenyl)-1,3-thiazol-5-yl]dihydro-2H-pyran-2,6-(3H)-dione (722549-30-6) + ethyl acetate (141-78-6) → 3-[2-(4-chlorophenyl)-1,3-thiazol-5-yl]-7-ethoxy-5,7-dioxoheptanoic acid (721920-85-0)

Guidance literature:

With lithium diisopropyl amide; at -78 ℃;

DOI:10.1016/j.bmcl.2006.03.045

Reference yield:

→ 3-[2-(4-chlorophenyl)-1,3-thiazol-5-yl]-7-ethoxy-5,7-dioxoheptanoic acid (721920-85-0)

Guidance literature:

Reference yield:

3-[2-(4-chlorophenyl)-1,3-thiazol-5-yl]-7-ethoxy-5,7-dioxoheptanoic acid (721920-85-0) → 3-[2-(4-chloro-phenyl)-thiazol-5-yl]-4-(3-hydroxy-isoxazol-5-yl)-butyric acid

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In water;

DOI:10.1016/j.bmcl.2006.03.045

upstream raw materials:

4-[2-(4-chlorophenyl)-1,3-thiazol-5-yl]dihydro-2H-pyran-2,6-(3H)-dione

ethyl acetate

Downstream raw materials:

3-[2-(4-chloro-phenyl)-thiazol-5-yl]-4-(3-hydroxy-isoxazol-5-yl)-butyric acid ethyl ester

3-[2-(4-chloro-phenyl)-thiazol-5-yl]-4-{3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-ethoxy]-isoxazol-5-yl}-butyric acid ethyl ester

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