2,8-Diazaspiro[4.5]decane-8-carboxylic acid,3-oxo-2-(phenylmethyl)-,1,1-dimethylethyl ester

Base Information

Chemical Name:2,8-Diazaspiro[4.5]decane-8-carboxylic acid,3-oxo-2-(phenylmethyl)-,1,1-dimethylethyl ester
CAS No.:169206-68-2
Molecular Formula:C20H28N2O3
Molecular Weight:344.44792
Hs Code.:
DSSTox Substance ID:DTXSID101134116

Synonyms:169206-68-2;2,8-Diazaspiro[4.5]decane-8-carboxylic acid,3-oxo-2-(phenylmethyl)-,1,1-dimethylethyl ester;SCHEMBL12447685;DTXSID101134116;1,1-Dimethylethyl 3-oxo-2-(phenylmethyl)-2,8-diazaspiro[4.5]decane-8-carboxylate

Suppliers and Price of 2,8-Diazaspiro[4.5]decane-8-carboxylic acid,3-oxo-2-(phenylmethyl)-,1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,8-Diazaspiro[4.5]decane-8-carboxylic acid,3-oxo-2-(phenylmethyl)-,1,1-dimethylethyl ester

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:344.20999276
Heavy Atom Count:25
Complexity:498

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC2(CC1)CC(=O)N(C2)CC3=CC=CC=C3

Technology Process of 2,8-Diazaspiro[4.5]decane-8-carboxylic acid,3-oxo-2-(phenylmethyl)-,1,1-dimethylethyl ester

There total 4 articles about 2,8-Diazaspiro[4.5]decane-8-carboxylic acid,3-oxo-2-(phenylmethyl)-,1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 100-39-0
benzyl bromide

: 169206-67-1
3-oxo-2,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester

: 169206-68-2
2-benzyl-3-oxo-2,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 12h; Heating;
DOI:10.1021/jm00019a006

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 169206-68-2
2-benzyl-3-oxo-2,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / toluene / 12 h / Heating

2: 35 percent / 1,1,3,3-tetramethylguanidine / 10 h / Heating

3: 81 percent / Raney Ni / ethanol; H₂O / 24 h / Ambient temperature

4: 99 percent / NaH / tetrahydrofuran / 12 h / Heating

With nickel; sodium hydride; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/jm00019a006

Reference yield:

: 169206-65-9
1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylene]piperidine

: 169206-68-2
2-benzyl-3-oxo-2,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / 1,1,3,3-tetramethylguanidine / 10 h / Heating

2: 81 percent / Raney Ni / ethanol; H₂O / 24 h / Ambient temperature

3: 99 percent / NaH / tetrahydrofuran / 12 h / Heating

With nickel; sodium hydride; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm00019a006