uridine (N-pac)-ce phosphoramidite*for abi

Base Information

• Chemical Name: uridine (N-pac)-ce phosphoramidite*for abi
• CAS No.: 169886-86-6
• Molecular Weight: 0
• Mol file: 169886-86-6.mol

Synonyms:URIDINE (N-PAC)-CE PHOSPHORAMIDITE*FOR A BI;N-blocked-5'-O-DMT-O-TBDMS CED uridine phosphoramidite

Chemical Property of uridine (N-pac)-ce phosphoramidite*for abi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of uridine (N-pac)-ce phosphoramidite*for abi

There total 4 articles about uridine (N-pac)-ce phosphoramidite*for abi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 5'-O-4,4'-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-6-methyluridine (169886-85-5) → (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (169886-86-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1080/15257770008035004

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (169886-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 92.2 percent / pyridine / 20 °C

2: 37 percent / AgNO₃; pyridine / tetrahydrofuran / 20 °C

3: 75 percent / iPr₂NEt / CH₂Cl₂

With pyridine; silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution / 3: Substitution;

DOI:10.1080/15257770008035004

Reference yield:

5'-O-4,4'-dimethoxytrityl-6-methyluridine (169886-81-1) → (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (169886-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / AgNO₃; pyridine / tetrahydrofuran / 20 °C

2: 75 percent / iPr₂NEt / CH₂Cl₂

With pyridine; silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution;

DOI:10.1080/15257770008035004

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

5'-O-4,4'-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-6-methyluridine

4,4'-dimethoxytrityl chloride

5'-O-4,4'-dimethoxytrityl-6-methyluridine