(R,R)-KW 3049

Base Information

Chemical Name:(R,R)-KW 3049
CAS No.:129262-07-3
Molecular Formula:C₂₈H₃₁N₃O₆*ClH
Molecular Weight:542.032
Hs Code.:
Mol file:129262-07-3.mol

Synonyms:(R,R)-KW 3049;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, [R-(R*,R*)]-;(-)-alfa-Benidipine Hydrochloride ((R,R)-Benidipine HCl);(-)-alfa-Benidipine-d5 Hydrochloride

Suppliers and Price of (R,R)-KW 3049

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(-)-α-BenidipineHydrochloride
1mg
$ 275.00

Total 10 raw suppliers

Chemical Property of (R,R)-KW 3049

Chemical Property:

PSA：113.69000
LogP:5.80230

Purity/Quality:

99% ^*data from raw suppliers

(-)-α-BenidipineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses The R-enantiomer

Technology Process of (R,R)-KW 3049

There total 17 articles about (R,R)-KW 3049 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

: 14813-01-5
1-benzyl-3-hydroxypiperidine

: 74936-72-4
5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

: 129262-07-3,85387-35-5,91599-76-7
KW 3049

Guidance literature:: 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid; With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; for 1h; Cooling with ice;

1-benzyl-3-hydroxypiperidine; In dichloromethane; N,N-dimethyl-formamide; at 20 - 30 ℃; for 1h;

With hydrogenchloride; In water; at 20 ℃; for 1h; Reagent/catalyst;

Reference yield: 36.2%

: 14813-01-5
1-benzyl-3-hydroxypiperidine

: 74936-72-4
5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

: 91599-74-5,129262-07-3,85387-35-5,91599-76-7
benidipine hydrochloride

Guidance literature:: 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 1h; Sonographic reaction; Cooling with ice;

1-benzyl-3-hydroxypiperidine; In dichloromethane; for 2.5h; Cooling with ice; Sonographic reaction;

Reference yield:

: 74936-72-4
5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

: 91599-74-5,129262-07-3,85387-35-5,91599-76-7
benidipine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide; CH₂Cl₂ / 1 h

2: dimethylformamide; CH₂Cl₂ / 2.5 h

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;