Ethyl 3-(2,3-difluorophenyl)-2-propenoate

Base Information

Chemical Name:Ethyl 3-(2,3-difluorophenyl)-2-propenoate
CAS No.:375368-90-4
Molecular Formula:C₁₁H₁₀F₂O₂
Molecular Weight:212.196
Hs Code.:
DSSTox Substance ID:DTXSID401272179
Mol file:375368-90-4.mol

Synonyms:DTXSID401272179;Ethyl 3-(2,3-difluorophenyl)-2-propenoate

Suppliers and Price of Ethyl 3-(2,3-difluorophenyl)-2-propenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AOBChem
Ethyl2,3-difluorocinnamate 97%
100g
$ 2685.00

AOBChem
Ethyl2,3-difluorocinnamate 97%
1g
$ 81.00

Total 4 raw suppliers

Chemical Property of Ethyl 3-(2,3-difluorophenyl)-2-propenoate

Chemical Property:

PSA：26.30000
LogP:2.54110
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:212.06488588
Heavy Atom Count:15
Complexity:241

Purity/Quality:

99%+ ^*data from raw suppliers

Ethyl2,3-difluorocinnamate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C=CC1=C(C(=CC=C1)F)F

Technology Process of Ethyl 3-(2,3-difluorophenyl)-2-propenoate

There total 2 articles about Ethyl 3-(2,3-difluorophenyl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2646-91-5
2,3-difluorobenzaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 375368-90-4
ethyl (E)-3-(2,3-difluorophenyl)acrylate

Guidance literature:: In dichloromethane; at 20 ℃; for 16h;
DOI:10.1080/00397911.2018.1455212

Reference yield:

: 367-11-3
ortho-difluorobenzene

: 140-88-5,9003-32-1
ethyl acrylate

: 375368-90-4
C₁₁H₁₀F₂O₂

: 375368-92-6
ethyl 3-(3,4-difluorophenyl)acrylate

Guidance literature:: With 3,5-bis(trifluoromethyl)pyridin-2(1H)-one; silver(I) acetate; palladium diacetate; at 100 ℃; for 24h; Overall yield = 60 %; regioselective reaction; Sealed tube;
DOI:10.1038/nature24632

Reference yield:

: 375368-90-4
ethyl (E)-3-(2,3-difluorophenyl)acrylate

: 141-97-9
ethyl acetoacetate

: C₁₅H₁₄F₂O₄

Guidance literature:: ethyl acetoacetate; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

ethyl (E)-3-(2,3-difluorophenyl)acrylate; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1080/00397911.2018.1455212