Technology Process of methyl 3-(hydroxymethyl)-2-methoxybenzoate
There total 2 articles about methyl 3-(hydroxymethyl)-2-methoxybenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
glucose dehydrogenase; β-D-glucose; β-nicotinamide adenine dinucleotide phosphate disodium salt; catalase from Micrococcus lysodeikticus; cytochrome P450 BM3 monooxygenase from Bacillus megaterium F87A, L188C double mutant; potassium chloride; oxygen; tris hydrochloride;
In
aq. phosphate buffer; dimethyl sulfoxide;
at 30 ℃;
for 24h;
pH=7.5;
Reagent/catalyst;
regioselective reaction;
Kinetics;
Catalytic behavior;
Green chemistry;
Enzymatic reaction;
DOI:10.1039/c3gc40838h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; magnesium sulfate / acetone / 34 h / 20 °C / Inert atmosphere; Reflux
2: cytochrome P450 BM3 monooxygenase from Bacillus megaterium F87A, L188C double mutant; tris hydrochloride; potassium chloride; β-nicotinamide adenine dinucleotide phosphate disodium salt; glucose dehydrogenase; β-D-glucose; oxygen; catalase from Micrococcus lysodeikticus / aq. phosphate buffer; dimethyl sulfoxide / 24 h / 30 °C / pH 7.5 / Green chemistry; Enzymatic reaction
With
glucose dehydrogenase; β-D-glucose; β-nicotinamide adenine dinucleotide phosphate disodium salt; catalase from Micrococcus lysodeikticus; cytochrome P450 BM3 monooxygenase from Bacillus megaterium F87A, L188C double mutant; potassium chloride; oxygen; tris hydrochloride; magnesium sulfate; potassium carbonate;
In
aq. phosphate buffer; dimethyl sulfoxide; acetone;
DOI:10.1039/c3gc40838h
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 0.5h;
DOI:10.1039/c3gc40838h
