methyl 3-formyl-2-methoxybenzoate

Base Information

• Chemical Name: methyl 3-formyl-2-methoxybenzoate
• CAS No.: 186312-96-9
• Molecular Formula: C10H10O4
• Molecular Weight: 194.18
• Mol file: 186312-96-9.mol

Synonyms:3-Formyl-2-methoxy-benzoic acid methyl ester;methyl 3-formyl-2-methoxybenzoate;

Chemical Property of methyl 3-formyl-2-methoxybenzoate

Chemical Property:

• Boiling Point: 328.1±27.0 °C(Predicted)
• PSA: 52.60000
• Density: 1.191±0.06 g/cm3(Predicted)
• LogP: 1.29430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-formyl-2-methoxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-formyl-2-methoxybenzoate

There total 3 articles about methyl 3-formyl-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-(hydroxymethyl)-2-methoxybenzoate (1427363-87-8) → methyl 2-methoxy-3-formylbenzoate (186312-96-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1039/c3gc40838h

Reference yield: 89.0%

3-formylsalicylic acid (610-04-8) + methyl iodide (74-88-4) → methyl 2-methoxy-3-formylbenzoate (186312-96-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; for 2h;

DOI:10.1016/S0968-0896(00)00345-X

Reference yield:

3-methylsalicylic acid (83-40-9) → methyl 2-methoxy-3-formylbenzoate (186312-96-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; magnesium sulfate / acetone / 34 h / 20 °C / Inert atmosphere; Reflux

2: cytochrome P450 BM3 monooxygenase from Bacillus megaterium F87A, L188C double mutant; tris hydrochloride; potassium chloride; β-nicotinamide adenine dinucleotide phosphate disodium salt; glucose dehydrogenase; β-D-glucose; oxygen; catalase from Micrococcus lysodeikticus / aq. phosphate buffer; dimethyl sulfoxide / 24 h / 30 °C / pH 7.5 / Green chemistry; Enzymatic reaction

3: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

With glucose dehydrogenase; β-D-glucose; β-nicotinamide adenine dinucleotide phosphate disodium salt; catalase from Micrococcus lysodeikticus; cytochrome P₄₅₀ BM₃ monooxygenase from Bacillus megaterium F₈₇A, L₁₈₈C double mutant; potassium chloride; oxygen; tris hydrochloride; magnesium sulfate; potassium carbonate; Dess-Martin periodane; In aq. phosphate buffer; dichloromethane; dimethyl sulfoxide; acetone;

DOI:10.1039/c3gc40838h

upstream raw materials:

3-formylsalicylic acid

methyl iodide

3-methylsalicylic acid

methyl 3-(hydroxymethyl)-2-methoxybenzoate

Downstream raw materials:

methyl 2-methoxy-3-(3-oxobutyl)benzoate

methyl 2-methoxy-3-(4-oxopentyl)benzoate

methyl 2-methoxy-3-(oxohexyl)benzoate

2-methoxyisophthalic acid monomethyl ester