1-N-[2-(dimethylamino)ethyl]benzene-1,4-diamine

Base Information

• Chemical Name: 1-N-[2-(dimethylamino)ethyl]benzene-1,4-diamine
• CAS No.: 263339-31-7
• Molecular Formula: C10H17N3
• Molecular Weight: 179.265
• Mol file: 263339-31-7.mol

Synonyms:1-N-[2-(dimethylamino)ethyl]benzene-1,4-diamine;N-[2-(DIMETHYLAMINO)ETHYL]-1,4-BENZENEDIAMINE;N1-[2-(dimethylamino)ethyl]-1,4-benzenediamine

Chemical Property of 1-N-[2-(dimethylamino)ethyl]benzene-1,4-diamine

Chemical Property:

• PSA: 41.29000
• LogP: 1.89650

Purity/Quality:

99% ^*data from raw suppliers

N-[2-(Dimethylamino)ethyl]-1,4-benzenediamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-[2-(dimethylamino)ethyl]benzene-1,4-diamine

There total 4 articles about 1-N-[2-(dimethylamino)ethyl]benzene-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-N'-(4-nitrophenyl)-ethane-1,2-diamine (25238-53-3) → N-(2-dimethylamino-ethyl)-benzene-1,4-diamine (263339-31-7)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 90 ℃; for 1h;

Reference yield:

2-(dimethylamino)ethyl chloride (107-99-3) + 1,4-phenylenediamine (106-50-3) → N-(2-dimethylamino-ethyl)-benzene-1,4-diamine (263339-31-7)

Guidance literature:

With potassium carbonate; potassium iodide; In toluene; for 20h; Reflux;

DOI:10.1016/j.bmc.2019.115127

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → N-(2-dimethylamino-ethyl)-benzene-1,4-diamine (263339-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: iron; ammonium chloride / ethanol; water / 1 h / 90 °C

With iron; potassium carbonate; ammonium chloride; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

2-(dimethylamino)ethyl chloride

1,4-phenylenediamine

4-Fluoronitrobenzene

N,N-dimethyl-N'-(4-nitrophenyl)-ethane-1,2-diamine

Refernces

• 1、 Chen, Guangying,Huang, Gangliang,Zhou, Shiyang. "Design, synthesis and biological activity of a novel ethylenediamine derivatives as H1 receptor antagonists". . . Retrieved 2019/11/21.