107-99-3Relevant articles and documents
Direct subphthalocyanine conjugation to bombesin: Vs. indirect conjugation to its lipidic nanocarrier
Bernhard, Yann,Gigot, Elodie,Goncalves, Victor,Moreau, Mathieu,Sok, Nicolas,Richard, Philippe,Decréau, Richard A.
, p. 4511 - 4518 (2016)
Bombesin (BBN) was covalently bound to graftable subphthalocyanine (SubPc) or to a cholesterol derivative, a component of a liposome that encapsulates non-graftable SubPc. The latter bioconjugation approach was suitable to address the stability of SubPc and was achieved by copper-free click-chemistry on the outer-face of the liposome. Liposomes were purified (FPLC) and then analyzed in size (outer diameter about 60 nm measured by DLS). In vitro binding studies allowed to determine the IC50 13.9 nM for one component of the liposome, cholesterol, conjugated to BBN. Hence, azido- (or alkynyl-) liposomes give fluorophores with no reactive functional group available on their backbone a second chance to be (indirectly) bioconjugated (with bombesin).
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Lerner et al.
, (1969)
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Isoflavone amide type derivative, preparation method and medical application thereof
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Paragraph 0016; 0080; 0081; 0082; 0089; 0090; 0091, (2016/10/10)
The invention relates to the field of medicinal chemistry, and relates to an isoflavone amide type derivative, a preparation method and a medical application thereof, in particular to an isoflavone amide type derivative with the general formula (I), a preparation method thereof, medicine compositions including the isoflavone amide type derivative and a medical application thereof, especially an application of the isoflavone amide type derivative as a medicine for preventing or curing hyperlipemia, obesity or type II diabetes. The general formula (I) is shown in the description.