Pyrazolo[1,5-a]pyrimidine-6-boronic acid pinacol eter

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyrimidine-6-boronic acid pinacol eter
• CAS No.: 1416437-27-8
• Molecular Formula: C₁₂H₁₆BN₃O₂
• Molecular Weight: 245.089
• Mol file: 1416437-27-8.mol

Synonyms:Pyrazolo[1,5-a]pyrimidine-6-boronic acid pinacol eter;6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazolo[1,5-a]pyrimidine;6-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine

Chemical Property of Pyrazolo[1,5-a]pyrimidine-6-boronic acid pinacol eter

Chemical Property:

• PSA: 48.65000
• LogP: 1.02850
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

6-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazolo[1,5-a]pyrimidine-6-boronic acid pinacol eter

There total 2 articles about Pyrazolo[1,5-a]pyrimidine-6-boronic acid pinacol eter which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

6-bromo-pyrazolo[1,5-α]pyrimidine (705263-10-1) + bis(pinacol)diborane (73183-34-3) → 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine (1416437-27-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In toluene; for 5h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2016.10.007

Reference yield:

→ 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine (1416437-27-8)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; CyJohnPhos; In tetrahydrofuran; at 80 ℃; for 3.61667h; Inert atmosphere;

Reference yield:

1-[2-(4-bromophenoxy)ethyl]pyrrolidine (1081-73-8) + 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine (1416437-27-8) → 6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 105 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmcl.2018.09.006

upstream raw materials:

6-bromo-pyrazolo[1,5-α]pyrimidine

bis(pinacol)diborane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1416437-27-8 Pyrazolo[1,5-a]pyrimidine-6-boronic acid pinacol eter

Send

Send

Metric Ton KG G Pound L ML

Send

Send