NA

Base Information

Chemical Name:NA
CAS No.:1338811-39-4
Molecular Formula:C30H27N5O3
Molecular Weight:505.576
Hs Code.:
Mol file:1338811-39-4.mol

Synonyms:Pyrrolo[1,2-a]pyrazin-1(2H)-one, 4-[(4-aminophenyl)methyl]-2-[(2,4-dimethoxyphenyl)methyl]-7-(1H-pyrrolo[2,3-b]pyridin-3-yl)-

Suppliers and Price of NA

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of NA

Chemical Property:

PSA：99.57000
LogP:5.46400

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Technology Process of NA

There total 11 articles about NA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338811-38-3
4-(4-aminobenzyl)-2-(2,4-dimethoxybenzyl)-7-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrolo[1,2-a]pyrazin-1(2H)-one

: 1338811-39-4
4-(4-aminobenzyl)-2-(2,4-dimethoxybenzyl)-7-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 50 ℃; for 4h;

Reference yield:

: 271-63-6
7-Azaindole

: 1338811-39-4
4-(4-aminobenzyl)-2-(2,4-dimethoxybenzyl)-7-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 4 h / -40 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

4.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 85 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 2068.65 Torr / Inert atmosphere

6.1: sodium hydroxide / 1,4-dioxane / 4 h / 50 °C

With N-Bromosuccinimide; hydrogen; potassium acetate; sodium hydride; caesium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1338811-39-4
4-(4-aminobenzyl)-2-(2,4-dimethoxybenzyl)-7-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol / 1.5 h / 20 °C

1.2: 2 h / 0 - 20 °C

2.1: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 20 °C

3.1: triethylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide; water / 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane; water / 6 h / Reflux

5.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 85 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 2068.65 Torr / Inert atmosphere

7.1: sodium hydroxide / 1,4-dioxane / 4 h / 50 °C

With copper(l) iodide; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; hydrogen; benzotriazol-1-ol; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Sonogashira Coupling / 5.1: Suzuki Coupling;