(1-Propyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Base Information

Chemical Name:(1-Propyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
CAS No.:1199943-42-4
Molecular Formula:C19H25NO
Molecular Weight:283.4079
Hs Code.:
Mol file:1199943-42-4.mol

Synonyms:(1-Propyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Suppliers and Price of (1-Propyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (1-Propyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Chemical Property:

PSA：22.00000
Density:1.05
LogP:4.91620

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1-Propyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

There total 3 articles about (1-Propyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 895152-66-6
(1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

: 106-94-5
propyl bromide

: 1199943-42-4
(1-propyl-1H-indole-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Guidance literature:: (1H-indole-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

propyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 45 ℃;
DOI:10.1021/jm901214q

Reference yield:

: 15641-58-4
2,2,3,3-tetramethylcyclopropane-1-carboxylic acid

: 1199943-42-4
(1-propyl-1H-indole-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: ethylmagnesium bromide / tetrahydrofuran; dichloromethane / 21 °C

2.2: 0.5 h

2.3: 6 h / 21 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.2: 0 - 45 °C

With thionyl chloride; ethylmagnesium bromide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm901214q

Reference yield:

: 24303-61-5
2,2,3,3-tetramethylcyclopropanecarbonyl chloride

: 1199943-42-4
(1-propyl-1H-indole-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / tetrahydrofuran; dichloromethane / 21 °C

1.2: 0.5 h

1.3: 6 h / 21 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2.2: 0 - 45 °C

With ethylmagnesium bromide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm901214q