2,2,3,3-tetramethylcyclopropane-1-carbonyl Chloride

Base Information

• Chemical Name: 2,2,3,3-tetramethylcyclopropane-1-carbonyl Chloride
• CAS No.: 24303-61-5
• Molecular Formula: C8H13ClO
• Molecular Weight: 160.644
• Hs Code.: 2916209090
• DSSTox Substance ID: DTXSID60452925
• Nikkaji Number: J23.516D
• Wikidata: Q72507553
• Mol file: 24303-61-5.mol

Synonyms:24303-61-5;2,2,3,3-tetramethylcyclopropane-1-carbonyl Chloride;2,2,3,3-tetramethylcyclopropanecarbonyl chloride;2,2,3,3-TETRAMETHYLCYCLOPROPANE CARBONYL CHLORIDE;2,2,3,3-tetramethyl-cyclopropanecarboxylic acid chloride;2,2,3,3-tetramethylcyclopropanecarbonylchloride;SCHEMBL926785;DTXSID60452925;PAPVPNRFJQMQLS-UHFFFAOYSA-N;AKOS015823622;tetramethylcyclopropanecarbonyl chloride;2,2,3,3-Tetramethylcyclopropanoyl chloride;TETRAMETHYLCYCLOPROPANE-1-CARBONYL CHLORIDE;2,2,3,3-tetramethyl-cyclopropane-carbonyl chloride;2,2,3,3-tetramethylcyclopropanecarboxylic acid chloride;2 pound not2 pound not3 pound not3-tetramethyl cyclopropane carboxynyl chloride

Chemical Property of 2,2,3,3-tetramethylcyclopropane-1-carbonyl Chloride

Chemical Property:

• Boiling Point: 152.823 °C at 760 mmHg
• Flash Point: 66.111 °C
• PSA: 17.07000
• Density: 1.028 g/cm³
• LogP: 2.43400
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Benzene, Chloroform
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 160.0654927
• Heavy Atom Count: 10
• Complexity: 168

Purity/Quality:

99% ^*data from raw suppliers

2,2,3,3-TetramethylcyclopropanecarbonylChloride(>90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(C(C1(C)C)C(=O)Cl)C
• Uses: 2,2,3,3-Tetramethylcyclopropanecarbonyl Chloride is a useful reagent for the preparation of potential 4-Hydroxy-5-fluoropentyl side-chain metabolites of synthetic cannabinoids.

Technology Process of 2,2,3,3-tetramethylcyclopropane-1-carbonyl Chloride

There total 3 articles about 2,2,3,3-tetramethylcyclopropane-1-carbonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

2,2,3,3-tetramethylcyclopropane-1-carboxylic acid (15641-58-4) → 2,2,3,3-tetramethylcyclopropanecarbonyl chloride (24303-61-5)

Guidance literature:

With oxalyl dichloride; In dichloromethane; at 20 ℃; for 0.8h;

Reference yield:

(3-bromo-2,6-dimethylphenyl)methanol (86246-72-2) → (3-bromo-2,6-dimethylphenyl)methyl 2,2,3,3-tetramethylcyclopropanecarboxylate + 2,2,3,3-tetramethylcyclopropanecarbonyl chloride (24303-61-5)

Guidance literature:

Reference yield:

→ 2,2,3,3-tetramethylcyclopropanecarbonyl chloride (24303-61-5)

Guidance literature:

DOI:10.1021/jf60165a009

upstream raw materials:

2,2,3,3-tetramethylcyclopropane-1-carboxylic acid

(3-bromo-2,6-dimethylphenyl)methanol

Downstream raw materials:

2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid 2-(2,4-dimethyl-phenyl)-5,5-dimethyl-3-oxo-cyclohex-1-enyl ester

fenpropathrin

2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid 4-(2-benzyloxycarbonyl-ethyl)-phenyl ester

2,2,3,3-Tetramethyl-cyclopropanecarboxylic acid cyano-[3-(4-nitro-phenoxy)-phenyl]-methyl ester

Refernces

• 1、 Sobol, Eyal,Bialer, Meir,Yagen, Boris. "Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives". . p. 4316 - 4326. Retrieved 2004.
• 2、 Salikov, Rinat F.,Platonov, Dmitry N.,Frumkin, Aleksandr E.,Lipilin, Dmitry L.,Tomilov, Yury V.. "Synthesis of 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazoles via the cyclopropyliminium rearrangement of substituted 2-cyclopropylbenzimidazoles". . p. 3495 - 3505. Retrieved 2013/04/23.