4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-ol

Base Information

Chemical Name:4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-ol
CAS No.:188534-03-4
Molecular Formula:C₁₆H₁₃FO₂
Molecular Weight:256.276
Hs Code.:
DSSTox Substance ID:DTXSID50599353

Synonyms:188534-03-4;4-[3-(4-fluorophenoxy)phenyl]-3-butyn-2-ol;SCHEMBL8198163;DTXSID50599353;UATKCSOGBBYBBZ-UHFFFAOYSA-N

Suppliers and Price of 4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-ol

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:256.08995782
Heavy Atom Count:19
Complexity:335

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C#CC1=CC(=CC=C1)OC2=CC=C(C=C2)F)O

Technology Process of 4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-ol

There total 1 articles about 4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188534-03-4
4-[3-(4-fluorophenoxy)phenyl]-3-butyn-2-ol

: 141579-54-6
N-hydroxy-N-[4-(3-(4-fluorophenoxy)-phenyl)-3-butyn-2-yl]urea

Guidance literature:

Reference yield:

: 188534-03-4
4-[3-(4-fluorophenoxy)phenyl]-3-butyn-2-ol

: 188534-07-8
N-[4-(3-(4-fluorophenoxy)phenyl)-3-butyn-2-yl]hydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Ambient temperature

2: TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

With di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm9700474

Reference yield:

: 188534-03-4
4-[3-(4-fluorophenoxy)phenyl]-3-butyn-2-ol

: 141579-54-6
N-hydroxy-N-[4-(3-(4-fluorophenoxy)-phenyl)-3-butyn-2-yl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Ambient temperature

2: TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

3: dioxane; tetrahydrofuran / 1 h / 90 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm9700474