pobilukast

Base Information

Chemical Name:pobilukast
CAS No.:107023-41-6
Molecular Formula:C26H34 O5 S
Molecular Weight:458.619
Hs Code.:
Mol file:107023-41-6.mol

Synonyms:Benzenepropanoicacid, b-[(2-carboxyethyl)thio]-a-hydroxy-2-(8-phenyloctyl)-,[R-(R*,S*)]-; Pobilukast; SKF 104353

Suppliers and Price of pobilukast

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of pobilukast

Chemical Property:

Vapor Pressure:6.33E-19mmHg at 25°C
Boiling Point:671.1°Cat760mmHg
Flash Point:359.7°C
PSA：120.13000
Density:1.198g/cm³
LogP:5.50690

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Anti-asthmatic(leukotriene antagonist).

Technology Process of pobilukast

There total 17 articles about pobilukast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: *,S^*)>-β-<(2-Carboxyethyl)thio>-α-hydroxy-2-(80phenyloctyl)benzenepropanoic acid diammonium salt

: 107023-41-6
pobilukast

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 0.0833333h;
DOI:10.1021/jo00075a019

Reference yield:

: 463308-95-4
phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate

: 107023-41-6
pobilukast

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 16h;
DOI:10.1021/ja0272540

Reference yield:

: 96964-45-3
2-(8-phenyloctyl) benzaldehyde

: 107023-41-6
pobilukast

Guidance literature:: Multi-step reaction with 4 steps

1: KOH / methanol / 48 h / -50 °C

2: DDQ / dioxane / 8 h / 85 °C

3: Yb(OTf)3 / tetrahydrofuran / -78 - 20 °C

4: aq. NaOH / methanol / 16 h / 20 °C

With potassium hydroxide; sodium hydroxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; ytterbium(III) triflate; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/ja0568345