phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate

Base Information

Chemical Name:phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate
CAS No.:463308-95-4
Molecular Formula:C₃₃H₄₀O₅S
Molecular Weight:548.744
Hs Code.:

Synonyms:phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate

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Chemical Property of phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate

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Technology Process of phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate

There total 4 articles about phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2935-90-2
Methyl 3-mercaptopropionate

: 134915-53-0
phenyl (2R, 3S) 3-[2-(8-phenyl-octyl)-phenyl]-2,3-epoxy-propanoate

: 463308-95-4
phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate

Guidance literature:: With ytterbium(III) triflate; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ja0272540

Reference yield:

: 134915-36-9
(2R, 3S)-3-[2-(8-phenyl-octyl)-phenyl]-2,3-epoxy-1-phenylpropan-1-one

: 463308-95-4
phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Heating

2: Yb(OTf)3 / CH₂Cl₂ / -78 - 20 °C

With 3-chloro-benzenecarboperoxoic acid; ytterbium(III) triflate; In dichloromethane; 1: Baeyer-Villinger oxidation;
DOI:10.1021/ja0272540

Reference yield:

: 96964-45-3
2-(8-phenyloctyl) benzaldehyde

: 463308-95-4
phenyl (2S, 3R), 3-{[2-(methoxycarbonyl)ethyl]thio}-2-hydroxy-3-[2-(8-phenyloctyl)-phenyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: KOH / methanol / 24 h / -30 °C

2: tetrahydrofuran; cyclohexane; diethyl ether / 0.5 h / -78 °C

3: m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Heating

4: Yb(OTf)3 / CH₂Cl₂ / -78 - 20 °C

With potassium hydroxide; 3-chloro-benzenecarboperoxoic acid; ytterbium(III) triflate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; cyclohexane; 3: Baeyer-Villinger oxidation;
DOI:10.1021/ja0272540