2,4-Dibromo-3-hydroxypyridine

Base Information

• Chemical Name: 2,4-Dibromo-3-hydroxypyridine
• CAS No.: 129611-31-0
• Molecular Formula: C5H3Br2NO
• Molecular Weight: 252.893
• Mol file: 129611-31-0.mol

Synonyms:2,4-Dibromo-3-hydroxypyridine;2,4-dibromo-3-Pyridinol

Chemical Property of 2,4-Dibromo-3-hydroxypyridine

Chemical Property:

• Boiling Point: 322.5±37.0 °C(Predicted)
• PKA: 1.75±0.10(Predicted)
• PSA: 33.12000
• Density: 2.228±0.06 g/cm3(Predicted)
• LogP: 2.31220

Purity/Quality:

98%min ^*data from raw suppliers

2,4-Dibromopyridin-3-ol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dibromo-3-hydroxypyridine

There total 2 articles about 2,4-Dibromo-3-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-HYDROXYPYRIDINE (109-00-2) → 2-bromo-pyridin-3-ol (6602-32-0) + 2,6-dibromopyridin-3-ol (6602-33-1) + 2,4-Dibromo-3-hydroxypyridine (129611-31-0)

Guidance literature:

With sodium hydroxide; bromine; In water; for 3h;

DOI:10.1055/s-1990-26918

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) → 2,6-dibromopyridin-3-ol (6602-33-1) + 2,4-Dibromo-3-hydroxypyridine (129611-31-0)

Guidance literature:

With sodium hydroxide; bromine; In water; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1055/s-1990-26918

upstream raw materials:

3-HYDROXYPYRIDINE

Refernces

• 1、 Bourne, Gregory T.,Kuster, Daniel J.,Marshall, Garland R.. "Synthesis of the phenylpyridal scaffold as a helical peptide mimetic". supporting information; experimental part. p. 8439 - 8445. Retrieved 2010/09/08.