(4-fluoro-2-methylphenyl)hydrazine

Base Information

• Chemical Name: (4-fluoro-2-methylphenyl)hydrazine
• CAS No.: 439863-62-4
• Molecular Formula: C7H9FN2
• Molecular Weight: 176.621
• Mol file: 439863-62-4.mol

Synonyms:4-fluoro-2-methylphenylhydrazine hydrochloride;

Chemical Property of (4-fluoro-2-methylphenyl)hydrazine

Chemical Property:

• PSA: 38.05000
• LogP: 2.99500
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

(4-fluoro-2-methylphenyl)hydrazinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-fluoro-2-methylphenyl)hydrazine

There total 1 articles about (4-fluoro-2-methylphenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-fluor-2-methylaniline (452-71-1) → 1-(4-fluoro-2-methylphenyl)hydrazine hydrochloride (439863-62-4)

Guidance literature:

4-fluor-2-methylaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 2h;

With tin(ll) chloride; In water; at 0 - 20 ℃; for 12h;

DOI:10.1021/jm2011645

Reference yield: 79.0%

4,4,4-trifluoro-1-(8-fluoro-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-butane-1,3-dione + 1-(4-fluoro-2-methylphenyl)hydrazine hydrochloride (439863-62-4) → 8-fluoro-6-[1-(4-fluoro-2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:

With triethylamine; trifluoroacetic acid; In isopropyl alcohol; at 80 ℃; for 3h;

DOI:10.1021/jm2011645

Reference yield: 58.0%

3-Aminocrotononitrile (1118-61-2) + 1-(4-fluoro-2-methylphenyl)hydrazine hydrochloride (439863-62-4) → 1-(4-fluoro-2-methylphenyl)-3-methyl-1H-pyrazol-5-amine (1210048-52-4)

Guidance literature:

3-Aminocrotononitrile; 1-(4-fluoro-2-methylphenyl)hydrazine hydrochloride; With hydrogenchloride; In water; at 100 ℃; for 18h;

With sodium hydroxide; In water; pH=> 12;

upstream raw materials:

4-fluor-2-methylaniline

Downstream raw materials:

1-(4-fluoro-2-methylphenyl)-3-methyl-1H-pyrazol-5-amine

Refernces