benazeprilat

Base Information

• Chemical Name: benazeprilat
• CAS No.: 89747-91-1
• Molecular Formula: C₂₂H₂₄N₂O₅
• Molecular Weight: 396.443
• Mol file: 89747-91-1.mol

Synonyms:1H-1-Benzazepine-1-acetic acid, 3-((1-carboxy-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-;1H-1-Benzazepine-1-acetic acid, 3-((1-carboxy-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-;Benazeprilate;Benazeprilate [french];Benazeprilatum;Benazeprilatum [latin];Unii-jrm708L703

Chemical Property of benazeprilat

Chemical Property:

• PSA: 106.94000
• LogP: 2.55050

Purity/Quality:

Benazeprilate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benazeprilat

There total 12 articles about benazeprilat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(3S)-1-(carboxymethyl)-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one hydrochloride (86541-77-7,215447-89-5,88372-38-7) → (3S)-1-(carboxymethyl)-<<(1S)-1-carboxy-3-phenylpropyl>amino>-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one (86541-78-8,89747-91-1)

Guidance literature:

With sodium hydroxide; In methanol; for 18h; Ambient temperature;

DOI:10.1021/jm00148a023

Reference yield:

benazepril (86541-75-5,86499-21-0) → ethanol (64-17-5) + benazeprilate (86541-78-8,89747-91-1)

Guidance literature:

With Tris-HCl buffer; human liver carboxylesterase pI 4.5; at 37 ℃; pH=7.4; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1248/bpb.20.869

Reference yield:

benazepril hydrochloride (86541-74-4,215447-89-5,88372-38-7) → benazeprilate (86541-78-8,89747-91-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In methanol; water;

upstream raw materials:

(3S)-1-(carboxymethyl)-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one hydrochloride

benazepril

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

3,3-dichloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one

Refernces

• 1、 Hemdan. "Development and validation of different methods manipulating zero order and first order spectra for determination of the partially overlapped mixture benazepril and amlodipine: A comparative study". . p. 52 - 60. Retrieved 2016/05/02.
• 2、 -. "3-Amino-[1]-benzazepin-2-one-1-alkanoic acids". . . Retrieved 2008/06/13.