3-BROMO-3'-FLUOROBENZOPHENONE

Base Information

• Chemical Name: 3-BROMO-3'-FLUOROBENZOPHENONE
• CAS No.: 75762-58-2
• Molecular Formula: C13H8BrFO
• Molecular Weight: 279.1
• Hs Code.: 2914700090
• Mol file: 75762-58-2.mol

Synonyms:3-BROMO-3'-FLUOROBENZOPHENONE;(3-BroMophenyl)(3-fluorophenyl)Methanone

Chemical Property of 3-BROMO-3'-FLUOROBENZOPHENONE

Chemical Property:

• Vapor Pressure: 1.54E-05mmHg at 25°C
• Boiling Point: 365.7°C at 760 mmHg
• Flash Point: 175°C
• PSA: 17.07000
• Density: 1.485g/cm³
• LogP: 3.81920
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

(3-Bromophenyl)(3-fluorophenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-3'-FLUOROBENZOPHENONE

There total 2 articles about 3-BROMO-3'-FLUOROBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3-fluoro-N-methoxy-N-methylbenzamide (226260-01-1) + 1,3-dibromobenzene (108-36-1) → (3-bromophenyl)-(3-fluorophenyl)methanone (75762-58-2)

Guidance literature:

1,3-dibromobenzene; With iodine; magnesium; In diethyl ether; at 20 - 30 ℃; Inert atmosphere;

3-fluoro-N-methoxy-N-methylbenzamide; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.12.090

Reference yield:

→ (3-bromophenyl)-(3-fluorophenyl)methanone (75762-58-2)

Guidance literature:

m-Fluorbrombenzol, m-Brombenzoylchlorid;

DOI:10.1021/ja00986a026

Reference yield: 56.0%

(3-bromophenyl)-(3-fluorophenyl)methanone (75762-58-2) + thiosemicarbazide (79-19-6) → [(3-bromophenyl)-(3-fluorophenyl)ketone]thiosemicarbazone (1220124-06-0)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2009.12.090

upstream raw materials:

3-fluoro-N-methoxy-N-methylbenzamide

1,3-dibromobenzene

Downstream raw materials:

[(3-bromophenyl)-(3-fluorophenyl)ketone]thiosemicarbazone

Refernces