Benzene, 2-bromo-1-chloro-3-methyl-5-nitro-

Base Information

• Chemical Name: Benzene, 2-bromo-1-chloro-3-methyl-5-nitro-
• CAS No.: 89642-17-1
• Molecular Formula: C7H5BrClNO2
• Molecular Weight: 250.479
• Mol file: 89642-17-1.mol

Synonyms:Benzene, 2-bromo-1-chloro-3-methyl-5-nitro-;2-bromo-1-chloro-3-methyl-5-nitrobenzene

Chemical Property of Benzene, 2-bromo-1-chloro-3-methyl-5-nitro-

Chemical Property:

• Melting Point: 97 °C
• PSA: 45.82000
• LogP: 3.84230

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-1-chloro-3-methyl-5-nitro-benzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 2-bromo-1-chloro-3-methyl-5-nitro-

There total 1 articles about Benzene, 2-bromo-1-chloro-3-methyl-5-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

2-chloro-6-methyl-4-nitro-phenylamine (69951-02-6) → 2-bromo-1-chloro-3-methyl-5-nitrobenzene (89642-17-1)

Guidance literature:

With tert.-butylnitrite; copper(I) bromide; In acetonitrile; at 20 ℃; for 0.0833333h; Cooling with ice;

Reference yield: 29.0%

{[4-(3-Boranyl-dihydroxy-benzenesulfonyl)-5-methylsulfanyl-thiophen-2-yl]-imino-methyl}-carbamic acid tert-butyl ester + 2-bromo-1-chloro-3-methyl-5-nitrobenzene (89642-17-1) → {[4-(2'-Chloro-6'-methyl-4'-nitro-biphenyl-3-sulfonyl)-5-methylsulfanyl-thiophen-2-yl]-imino-methyl}-carbamic acid tert-butyl ester

Guidance literature:

Pd(PPh₃)4; In ethanol; sodium carbonate; toluene;

Reference yield:

2-bromo-1-chloro-3-methyl-5-nitrobenzene (89642-17-1) → C25H22ClF3N2O4

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; tetrahydrofuran; water / 2 h / 60 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butylphosphonium tetrafluoroborate / 1,4-dioxane / 3 h / 120 °C / Cooling with ice; Inert atmosphere; Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / Cooling with ice

3.2: 0.5 h / Cooling with ice

3.3: 20 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tin(II) chloride dihdyrate; tert-butylphosphonium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

upstream raw materials:

2-chloro-6-methyl-4-nitro-phenylamine