Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-

Base Information

Chemical Name:Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-
CAS No.:892128-60-8
Molecular Formula:C17H25F2N3O5
Molecular Weight:389.399
Hs Code.:
UNII:YLR364XYSA
ChEMBL ID:CHEMBL577711
DSSTox Substance ID:DTXSID001025742
Metabolomics Workbench ID:153801
NCI Thesaurus Code:C102856
Nikkaji Number:J3.206.210E
Wikidata:Q27294578
Mol file:892128-60-8.mol

Synonyms:LY2334737

Suppliers and Price of Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
LY2334737 >98%
100 mg
$ 550.00

DC Chemicals
LY2334737 >98%
250 mg
$ 1000.00

Crysdot
LY2334737 98+%
100mg
$ 866.00

Crysdot
LY2334737 98+%
10mg
$ 234.00

Crysdot
LY2334737 98+%
5mg
$ 154.00

Crysdot
LY2334737 98+%
50mg
$ 557.00

ChemScene
LY2334737 99.02%
50mg
$ 1026.00

ChemScene
LY2334737 99.02%
5mg
$ 283.00

ChemScene
LY2334737 99.02%
100mg
$ 1596.00

ChemScene
LY2334737 99.02%
10mg
$ 432.00

Total 12 raw suppliers

Chemical Property of Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-

Chemical Property:

PKA:9.66±0.20(Predicted)
PSA：117.17000
Density:1.41±0.1 g/cm3(Predicted)
LogP:1.11830
Solubility.:Soluble in DMSO
XLogP3:1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:389.17622723
Heavy Atom Count:27
Complexity:620

Purity/Quality:

99%, ^*data from raw suppliers

LY2334737 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC(CCC)C(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O)(F)F
Isomeric SMILES:CCCC(CCC)C(=O)NC1=NC(=O)N(C=C1)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F
Recent ClinicalTrials:A Study of LY2334737 in Participants With Cancer That is Advanced and/or Has Spread

Technology Process of Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-

There total 9 articles about Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1196664-00-2
C₂₇H₄₁F₂N₃O₉

: 892128-60-8
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; Inert atmosphere;
DOI:10.1021/jm901181h

Reference yield: 77.0%

: C₁₁H₁₈N₂O₂

: 892128-60-8
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide

Guidance literature:: gemcitabine; With chloro-trimethyl-silane; In pyridine; at 0 ℃; for 2h;

C₁₁H₁₈N₂O₂; In pyridine; acetonitrile; at 0 - 45 ℃;

In pyridine; acetonitrile; at 0 - 45 ℃;

Reference yield: 77.0%

: 99-66-1
valproic acid

: 892128-60-8
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide

Guidance literature:: gemcitabine; With pyridine; chloro-trimethyl-silane; at 0 - 5 ℃; for 2h;

valproic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 20 - 45 ℃;

With ethanol; phosphoric acid; water; more than 3 stages;