α-Amino-1-(aminoiminomethyl)-4-piperidineacetic acid

Base Information

• Chemical Name: α-Amino-1-(aminoiminomethyl)-4-piperidineacetic acid
• CAS No.: 41021-57-2
• Molecular Weight: 200.23824
• Mol file: 41021-57-2.mol

Synonyms:α-Amino-1-(aminoiminomethyl)-4-piperidineacetic acid

Chemical Property of α-Amino-1-(aminoiminomethyl)-4-piperidineacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-Amino-1-(aminoiminomethyl)-4-piperidineacetic acid

There total 5 articles about α-Amino-1-(aminoiminomethyl)-4-piperidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-(((benzyloxy)carbonyl)amino)-2-(1-carbamimidoylpiperidin-4-yl)acetic acid → (R)-2-amino-2-(1-carbamimidoylpiperidin-4-yl)acetic acid (41021-57-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;

Reference yield:

4-((R)-benzyloxycarbonylamino-carboxy-methyl)piperidine-1-carboxylic acid tert-butyl ester (400888-22-4) → (R)-2-amino-2-(1-carbamimidoylpiperidin-4-yl)acetic acid (41021-57-2)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Cooling with ice

4: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(R)-2-(((benzyloxy)carbonyl)amino)-2-(piperidin-4-yl)acetic acid → (R)-2-amino-2-(1-carbamimidoylpiperidin-4-yl)acetic acid (41021-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Cooling with ice

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-((R)-benzyloxycarbonylamino-carboxy-methyl)piperidine-1-carboxylic acid tert-butyl ester

4-((R)-amino-carboxy-methyl)piperidine-1-carboxylic acid tert-butyl ester

Refernces