Bicyclo[2.2.1]heptane-2-acetonitrile, 2-hydroxy-1,3,3-trimethyl-, (1R,2S,4S)- (9CI)

Base Information

Chemical Name:Bicyclo[2.2.1]heptane-2-acetonitrile, 2-hydroxy-1,3,3-trimethyl-, (1R,2S,4S)- (9CI)
CAS No.:439689-16-4
Molecular Formula:C₁₂H₁₉NO
Molecular Weight:193.289
Hs Code.:
Mol file:439689-16-4.mol

Synonyms:Bicyclo[2.2.1]heptane-2-acetonitrile, 2-hydroxy-1,3,3-trimethyl-, (1R,2S,4S)- (9CI)

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Chemical Property of Bicyclo[2.2.1]heptane-2-acetonitrile, 2-hydroxy-1,3,3-trimethyl-, (1R,2S,4S)- (9CI)

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Technology Process of Bicyclo[2.2.1]heptane-2-acetonitrile, 2-hydroxy-1,3,3-trimethyl-, (1R,2S,4S)- (9CI)

There total 6 articles about Bicyclo[2.2.1]heptane-2-acetonitrile, 2-hydroxy-1,3,3-trimethyl-, (1R,2S,4S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 7787-20-4,126-21-6
(1R)-fenchone

: 75-05-8,26809-02-9
acetonitrile

: 366013-96-9,324538-17-2,439689-16-4
2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)acetonitrile

Guidance literature:: acetonitrile; With n-butyllithium; In tetrahydrofuran; hexane; at -85 ℃; for 0.75h; Inert atmosphere;

(1R)-fenchone; In tetrahydrofuran; hexane; at -85 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.03.025

Reference yield: 81.0%

: 7787-20-4,126-21-6
(1R)-fenchone

: C₄H₈O*C₂H₂LiN

: 366013-96-9,324538-17-2,439689-16-4
2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)acetonitrile

Guidance literature:: (1R)-fenchone; With cerium(III) chloride; In tetrahydrofuran; at 20 ℃; for 1h;

C₄H₈O*C₂H₂LiN; at -78 - 20 ℃;
DOI:10.1016/S0957-4166(01)00221-X