methyl 5-(4-hydroxyphenyl)isoxazole-3-carboxylate

Base Information

• Chemical Name: methyl 5-(4-hydroxyphenyl)isoxazole-3-carboxylate
• CAS No.: 60640-71-3
• Molecular Formula: C₁₁H₉NO₄
• Molecular Weight: 219.197
• Hs Code.: 2934999090
• Mol file: 60640-71-3.mol

Synonyms:methyl 5-(4-hydroxyphenyl)isoxazole-3-carboxylate;3-isoxazolecarboxylic acid, 5-(4-hydroxyphenyl)-, methyl ester;3-isoxazolecarboxylic acid, 5-(4-hydroxyphenyl)-, methyl e;5-(4-hydroxyphenyl)-3-Isoxazolecarboxylic acid methyl ester;5-(4-hydroxy-phenyl)-isoxazole-3-carboxylic acid methyl ester

Chemical Property of methyl 5-(4-hydroxyphenyl)isoxazole-3-carboxylate

Chemical Property:

• PSA: 72.56000
• LogP: 1.83380
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-(4-Hydroxyphenyl)isoxazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-(4-hydroxyphenyl)isoxazole-3-carboxylate

There total 2 articles about methyl 5-(4-hydroxyphenyl)isoxazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-hydroxy-phenyl)-2,4-dioxo-butyric acid methyl ester (39757-33-0) → 5-(4-hydroxy-phenyl)-isoxazole-3-carboxylic acid methyl ester (60640-71-3)

Guidance literature:

With hydroxyammonium sulfate; In methanol; for 0.25h; Heating;

DOI:10.1248/cpb.24.1757

Reference yield:

4-Hydroxyacetophenone (99-93-4) → 5-(4-hydroxy-phenyl)-isoxazole-3-carboxylic acid methyl ester (60640-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe / methanol

2: aq. NH₂OH*0.5 H₂SO₄ / methanol / 0.25 h / Heating

With hydroxyammonium sulfate; sodium methylate; In methanol;

DOI:10.1248/cpb.24.1757

Reference yield:

5-(4-hydroxy-phenyl)-isoxazole-3-carboxylic acid methyl ester (60640-71-3) → 1-[5-(4-acetoxy-phenyl)-isoxazol-3-yl]-ethanone (60640-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / diethyl ether; tetrahydrofuran

2: NaOAc / 2 h / 110 °C

With sodium acetate; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1248/cpb.24.1757

upstream raw materials:

4-(4-hydroxy-phenyl)-2,4-dioxo-butyric acid methyl ester

4-Hydroxyacetophenone

Downstream raw materials:

1-[5-(4-hydroxy-phenyl)-isoxazol-3-yl]-ethanone

1-[5-(4-acetoxy-phenyl)-isoxazol-3-yl]-ethanone

1-[5-(4-acetoxy-phenyl)-isoxazol-3-yl]-2-bromo-ethanone

4-[3-(1-hydroxy-2-piperidin-1-yl-ethyl)-isoxazol-5-yl]-phenol

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