D-HoMophenylalanine tert-Butyl Ester

Base Information

• Chemical Name: D-HoMophenylalanine tert-Butyl Ester
• CAS No.: 740055-30-5
• Molecular Formula: C14H21NO2
• Molecular Weight: 235.32204
• Mol file: 740055-30-5.mol

Synonyms:D-HoMophenylalanine tert-Butyl Ester;(R)-alpha-Aminobenzenebutanoic acid 1,1-dimethylethyl ester

Chemical Property of D-HoMophenylalanine tert-Butyl Ester

Chemical Property:

• PSA: 52.32000
• LogP: 2.98850

Purity/Quality:

97% ^*data from raw suppliers

D-Homophenylalaninetert-ButylEster 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-HoMophenylalanine tert-Butyl Ester

There total 2 articles about D-HoMophenylalanine tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

t-butyl 2-oxo-4-phenylbutanoate → (R)-tert-butyl 2-amino-4-phenylbutanoate (740055-30-5)

Guidance literature:

t-butyl 2-oxo-4-phenylbutanoate; With C₄₃H₅₅N₃O₃S; 2-CHLOROBENZYLAMINE; In benzene; at 50 ℃; for 60h; Molecular sieve; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In tetrahydrofuran; benzene; Solvent; Reagent/catalyst; enantioselective reaction;

DOI:10.1021/ol302427d

Reference yield:

t-butyl 2-oxo-4-phenylbutanoate → (R)-tert-butyl 2-amino-4-phenylbutanoate (740055-30-5) + (S)-α-(2-phenylethyl)glycine, tert-butyl ester (83079-77-0)

Guidance literature:

t-butyl 2-oxo-4-phenylbutanoate; With 2-Hydroxybenzylamine; C₂₃H₃₀N₂O₂; In benzene; at 25 ℃; for 48h; Inert atmosphere; Molecular sieve;

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 5h;

With sodium hydrogencarbonate; In water; pH=8; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tet.2012.06.023

Reference yield: 100.0%

(R)-tert-butyl 2-amino-4-phenylbutanoate (740055-30-5) → (R)-2-amino-4-phenylbutanoic acid hydrochloride (105382-09-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 100 ℃; for 12h;

DOI:10.1021/ol302427d

Downstream raw materials:

C₂₅H₂₉NO₄S

(R)-N-hydroxy-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-4-phenyl-butyramide

C₂₉H₃₁NO₄

(R)-2-amino-4-phenylbutanoic acid hydrochloride

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