83079-77-0

Usage

Uses

Used in Pharmaceutical Industry:
(S) ALFA AMINOBENZENEBUTANOIC ACID 1,1-DIMETHYLETHYL ESTER is used as an intermediate in the production of various drugs for its ability to facilitate the synthesis of potential therapeutic agents.
Used in Neuroactive Drug Development:
In the field of neuroactive drug development, (S) ALFA AMINOBENZENEBUTANOIC ACID 1,1-DIMETHYLETHYL ESTER is used as a key component for creating medications that can cross the blood-brain barrier, targeting central nervous system disorders.
Used in Anti-Epileptic and Anti-Convulsant Medication Synthesis:
(S) ALFA AMINOBENZENEBUTANOIC ACID 1,1-DIMETHYLETHYL ESTER is utilized as a precursor in the synthesis of potential anti-epileptic and anti-convulsant medications, due to its interaction with the central nervous system and its potential to mitigate seizure activity.
Used in Treatment of Anxiety, Insomnia, and Mood Disorders:
In the therapeutic applications for mental health, (S) ALFA AMINOBENZENEBUTANOIC ACID 1,1-DIMETHYLETHYL ESTER is used as a component in the development of treatments for anxiety, insomnia, and mood disorders, leveraging its neuroactive properties to address these conditions effectively.

InChI:InChI=1/C14H21NO2.ClH/c1-14(2,3)17-13(16)12(15)10-9-11-7-5-4-6-8-11;/h4-8,12H,9-10,15H2,1-3H3;1H/t12-;/m0./s1

Upstream product

• 943-73-7 D-homophenylalanine 
• 115-11-7 isobutene 

Downstream Products

• 147484-88-6 N-<1(R)-(benzyloxycarbonyl)ethyl>-α-(S)-(2-phenylethyl)glycine, tert-butyl ester 
• 401791-61-5 (S)-5-(1-tert-butoxycarbonyl-3-phenyl-propylcarbamoyl)-benzoimidazole-1-carboxylic acid tert-butyl ester 
• 1393687-40-5 C₂₁H₂₅NO₃ 

Relevant academic research and scientific papers

Asymmetric Synthesis of α-Amino Acids by Organocatalytic Biomimetic Transamination

A biomimetic enantioselective transamination of α-keto ester derivatives can be realized under mild conditions by using chiral quaternary ammonium arenecarboxylates in the absence of base additives. The corresponding α-amino acids can be used as versatile intermediates for further synthetic transformations that furnish chiral pyrrolidine and octahydroindolizine derivatives.

An efficient asymmetric biomimetic transamination of α-keto esters to chiral α-amino esters

An efficient asymmetric biomimetic transamination of α-keto esters with quinine derivatives as chiral bases was described. A wide variety of α-amino esters containing various functional groups can be synthesized in high yield and enantioselectivity.

The effect of benzyl amine on the efficiency of the base-catalyzed transamination of α-keto esters

This paper describes the effect of benzyl amine on the base-catalyzed transamination of α-keto esters. Among various benzyl amines examined, o-HOC6H4CH2NH2 was found to be highly effective for the reaction, affording a wide variety of α-amino esters in good yields. The o-OH group of the benzyl amine facilitates the transamination process likely via H-bond. Moderate enantiomeric excess was obtained for α-amino ester when a quinine derived catalyst was used.

Neutrophil inhibitors to reduce inflammatory response

The invention provides novel compounds selected from the group consisting of: The compounds of the present invention are useful for the treatment and prevention of a variety of diseases and conditions associated with undesirable or abnormal inflammatory responses, such as ischemia-reperfusion injury. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment or prevention for the above disorders using theses compounds or the compositions containing them.