Ethyl 2-(5-(5-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate

Base Information

Chemical Name:Ethyl 2-(5-(5-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate
CAS No.:1030613-24-1
Molecular Formula:C₁₈H₁₉BrFN₇O₃S
Molecular Weight:512.362
Hs Code.:
Mol file:1030613-24-1.mol

Synonyms:Ethyl 2-(5-(5-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate;ethyl (5-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1H-tetrazol-1-yl)acetate

Suppliers and Price of Ethyl 2-(5-(5-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl2-(5-(5-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate
25mg
$ 330.00

Total 3 raw suppliers

Chemical Property of Ethyl 2-(5-(5-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate

Chemical Property:

PSA：136.39000
LogP:2.76910

Purity/Quality:

99.0% ^*data from raw suppliers

Ethyl2-(5-(5-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Ethyl 2-(5-(5-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate is an intermediate in the synthesis of azacycloalkane derivatives as inhibitors of stearoyl-CoA desaturase.

Technology Process of Ethyl 2-(5-(5-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate

There total 6 articles about Ethyl 2-(5-(5-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-1H-tetrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1030613-20-7
4-(2-bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-1,3,4-thiadiazol-2-yl]piperidine

: 105-36-2
ethyl bromoacetate

: 1030613-22-9
ethyl (5-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-2H-tetrazol-2-yl)acetate

: 1030613-24-1
ethyl (5-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1H-tetrazol-1-yl)acetate

Guidance literature:: 4-(2-bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-1,3,4-thiadiazol-2-yl]piperidine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -78 - 0 ℃;

ethyl bromoacetate; In N,N-dimethyl-formamide; mineral oil; at -78 - 20 ℃;

With hydrogenchloride; In water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200319u

Reference yield:

: 1020658-57-4
5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazole-2-carbonitrile

: 1030613-22-9
ethyl (5-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-2H-tetrazol-2-yl)acetate

: 1030613-24-1
ethyl (5-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1H-tetrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide; pyridine hydrochloride / 1-methyl-pyrrolidin-2-one / 4 h / 130 °C

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -78 - 0 °C

2.2: -78 - 20 °C

With sodium azide; pyridine hydrochloride; sodium hydride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200319u

Reference yield:

: 147460-41-1
2-bromo-5-fluorophenol

: 1030613-22-9
ethyl (5-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-2H-tetrazol-2-yl)acetate

: 1030613-24-1
ethyl (5-{5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}-1H-tetrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran; dichloromethane / -78 - 20 °C

1.2: 24 h / -78 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 20 °C

3.1: sodium azide; pyridine hydrochloride / 1-methyl-pyrrolidin-2-one / 4 h / 130 °C

3.2: 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -78 - 0 °C

4.2: -78 - 20 °C

With sodium azide; di-tert-butyl-diazodicarboxylate; pyridine hydrochloride; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200319u