1,3,3-TriMethyl-2-[(1E,3E)-3-Methyl-6-(triMethylsilyl)-1,3-hexadien-5-yn-1-yl]-cyclohexene

Base Information

Chemical Name:1,3,3-TriMethyl-2-[(1E,3E)-3-Methyl-6-(triMethylsilyl)-1,3-hexadien-5-yn-1-yl]-cyclohexene
CAS No.:228120-22-7
Molecular Formula:C₁₉H₃₀Si
Molecular Weight:286.533
Hs Code.:
Mol file:228120-22-7.mol

Synonyms:1,3,3-TriMethyl-2-[(1E,3E)-3-Methyl-6-(triMethylsilyl)-1,3-hexadien-5-yn-1-yl]-cyclohexene;TriMethyl[(3E,5E)-4-Methyl-6-(2,6,6-triMethyl-1-cyclohexen-1-yl)-3,5-hexadien-1-ynyl]silane

Suppliers and Price of 1,3,3-TriMethyl-2-[(1E,3E)-3-Methyl-6-(triMethylsilyl)-1,3-hexadien-5-yn-1-yl]-cyclohexene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,3,3-Trimethyl-2-[(1E,3E)-3-methyl-6-(trimethylsilyl)-1,3-hexadien-5-yn-1-yl]-cyclohexene
250mg
$ 1320.00

Total 2 raw suppliers

Chemical Property of 1,3,3-TriMethyl-2-[(1E,3E)-3-Methyl-6-(triMethylsilyl)-1,3-hexadien-5-yn-1-yl]-cyclohexene

Chemical Property:

Boiling Point:358.8±9.0 °C(Predicted)
PSA：0.00000
Density:0.900±0.06 g/cm3(Predicted)
LogP:5.89630
Solubility.:Chloroform, Dichloromethane, Hexanes

Purity/Quality:

97% ^*data from raw suppliers

1,3,3-Trimethyl-2-[(1E,3E)-3-methyl-6-(trimethylsilyl)-1,3-hexadien-5-yn-1-yl]-cyclohexene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Intermediate in the preparation of Retinoic Acid derivatives.

Technology Process of 1,3,3-TriMethyl-2-[(1E,3E)-3-Methyl-6-(triMethylsilyl)-1,3-hexadien-5-yn-1-yl]-cyclohexene

There total 2 articles about 1,3,3-TriMethyl-2-[(1E,3E)-3-Methyl-6-(triMethylsilyl)-1,3-hexadien-5-yn-1-yl]-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-77-6,14901-07-6
(E)-β-ionone

: 135217-63-9
(3-trimethylsilanyl-prop-2-ynyl)-phosphonic acid diethyl ester

: trimethyl((3Z,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-enyl)hexa-3,5-dien-1-ynyl)silane

: 228120-22-7
trimethyl((3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-enyl)hexa-3,5-dien-1-ynyl)silane

Guidance literature:: (3-trimethylsilanyl-prop-2-ynyl)-phosphonic acid diethyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -10 ℃; for 1h; Inert atmosphere;

(E)-β-ionone; In tetrahydrofuran; at 0 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1002/chem.201102570

Reference yield:

: 5272-36-6
3-trimethylsilyl-2-propyn-1-ol

: trimethyl((3Z,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-enyl)hexa-3,5-dien-1-ynyl)silane

: 228120-22-7
trimethyl((3E,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-enyl)hexa-3,5-dien-1-ynyl)silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus tribromide / -5 - 20 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere

2.2: 1 h / -10 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

With sodium hexamethyldisilazane; phosphorus tribromide; In tetrahydrofuran; 3.1: Horner-Wadsworth-Emmons olefination / 3.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1002/chem.201102570