1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 1-(3-BORONOPHENYL)-1,4-DIHYDRO-4-OXO-, 3-ETHYL ESTER

Base Information

Chemical Name:1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 1-(3-BORONOPHENYL)-1,4-DIHYDRO-4-OXO-, 3-ETHYL ESTER
CAS No.:694489-60-6
Molecular Formula:C17H15BN2O5
Molecular Weight:338.127
Hs Code.:
Mol file:694489-60-6.mol

Synonyms:1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 1-(3-BORONOPHENYL)-1,4-DIHYDRO-4-OXO-, 3-ETHYL ESTER;3-(3-(ethoxycarbonyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)phenylboronic acid

Suppliers and Price of 1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 1-(3-BORONOPHENYL)-1,4-DIHYDRO-4-OXO-, 3-ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
1-(3-BORONOPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID-3-ETHYL ESTER 95.00%
5MG
$ 505.08

Total 0 raw suppliers

Chemical Property of 1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 1-(3-BORONOPHENYL)-1,4-DIHYDRO-4-OXO-, 3-ETHYL ESTER

Chemical Property:

Melting Point:273 °C
PSA：101.65000
LogP:0.24220

Purity/Quality:: 1-(3-BORONOPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID-3-ETHYL ESTER 95.00% ^*data from reagent suppliers

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Technology Process of 1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 1-(3-BORONOPHENYL)-1,4-DIHYDRO-4-OXO-, 3-ETHYL ESTER

There total 2 articles about 1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 1-(3-BORONOPHENYL)-1,4-DIHYDRO-4-OXO-, 3-ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 49609-84-9
2-Chloronicotinoyl chloride

: 1117-37-9
ethyl (E)-3-(dimethylamino)acrylate

: 85006-23-1
3-aminophenylboronic acid hydrochloric salt

: 694489-60-6
ethyl 1-(phenyl-3-dihydroxyboranyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxylate

Guidance literature:: 2-Chloronicotinoyl chloride; ethyl (E)-3-(dimethylamino)acrylate; With triethylamine; In toluene; at 70 ℃; for 5h;

3-aminophenylboronic acid hydrochloric salt; With potassium phosphate; In N,N-dimethyl acetamide; at 70 ℃; for 18h;
DOI:10.1016/j.tet.2005.03.143