49609-84-9Relevant articles and documents
Substituted-nicotinyl thiourea derivatives bearing pyrimidine moiety: Synthesis and biological evaluation
Ke, Shaoyong,Cao, Xiufang
, p. 627 - 633 (2011)
A series of substituted-nicotinyl thiourea derivatives containing pyrimidine ring were synthesized in good to excellent yield using PEG-400 as solid-liquid phase transfer catalyst under ultrasonic irradiation. The structures of all newly synthesized compounds were elucidated and confirmed by IR, 1H NMR and elemental analysis. The preliminary biological tests show that some of the target compounds present good inhibitory activities against the root and stalk of dicotyledon plants and are safe for monocotyledon plants.
NAD(P+/NAD(P)H models. 83. Molecular asymmetry with a carbonyl group: Electronically controlled stereochemistry in the reaction of NAD(P)+/NAD(P)H analogs
Ohno,Tsutsumi,Kawai,Yamazaki,Mikata,Okamura
, p. 8133 - 8137 (1994)
The N-methylpyridinium salt of 6,7-dihydro-6-methyl-5-oxopyridino[3,2-d]-2-benzazepin has been synthesized. The salt has axial chirality with respect to the orientation of the carbonyl dipole. An enantiomer of the cation has been obtained as the iodide sa
Synthesis and process optimization of Boscalid by catalyst Pd-PEPPSI-IPrDtBu-An
Xu, Jian,Lan, Xiao-Bing,Xia, Lin-Jian,Yang, Yi,Cao, Gao
, p. 247 - 256 (2021/05/06)
The purpose of this research was to reduce the amount of noble metal palladium catalyst and improve the catalytic performance in the Suzuki–Miyaura cross-coupling reaction, which is the key step in the synthesis of Boscalid. Taking o-bromonitrobenzene and p-chlorophenylboronic acid as raw materials, three kinds of Pd-PEPPSI-IPr catalysts were synthesized and employed in the Suzuki reaction, and then the biaryl product was subjected to reduction and condensation reaction to give Boscalid. Under the optimal reaction conditions, the result showed that the catalytic system exhibits highest catalytic efficiency under aerobic conditions, giving the 2-(4-chlorophenyl)nitrobenzene in over 99 % yield. Moreover, the Pd-PEPPSI-IPrDtBu-An catalyst was minimized to 0.01 mol%. The synthesis process was mild, the post-treatment was simple, and the production cost was reduced, which makes it suitable for industrial production.
New green technology for preparation of 2-chloronicotinic acid
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Paragraph 0026; 0028; 0030; 0032, (2019/01/24)
The invention relates to a new green technology for preparation of 2-chloronicotinic acid. The technology includes: adopting nicotinic acid (I) as the raw material, conducting hydrogen peroxide N-oxidation under the action of a catalyst in a water system to obtain nicotinic acid N-oxide (II), then under the action of organic base, conducting phosphorus oxychloride chlorination to synthesize 2-chloronicotinyl chloride (III), and then performing hydrolysis and refining to obtain 2-chloronicotinic acid (IV). The method avoids the use of benzene and acetic acid, has the advantages of short process, safety and environmental protection, good product quality and high yield, is an environment-friendly green synthetic route, and is suitable for industrial production.
A fluorine-containing thiazole aromatic amide compound and use thereof
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Paragraph 0020; 0021, (2018/03/26)
The invention discloses a thiazole fluoride-containing aromatic amide compound, which has a structure as shown in the general formula I in the description, wherein R is shown in the description. The compound shown in the general formula I has excellent st
