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49609-84-9 Usage


2-Chloronicotinyl chloride is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds and pharmaceuticals. It is characterized by its reactive chlorine atom attached to a nicotinyl group, which allows it to participate in numerous chemical reactions and form a wide range of products.


Used in Pesticide Industry:
2-Chloronicotinyl chloride is used as an intermediate in the production of the synergistic pesticide Boscalid. This pesticide is known for its effectiveness in controlling various pests and diseases in crops, thereby enhancing agricultural productivity and crop protection.
Used in Pharmaceutical Industry:
2-Chloronicotinyl chloride is also utilized in the preparation of thieno[2.3-b]pyrrole derivatives, which are cannabinoid receptor agonists. These agonists have potential applications in the monoand combination therapy of various diseases, offering new treatment options and improving patient outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 49609-84-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,6,0 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 49609-84:
159 % 10 = 9
So 49609-84-9 is a valid CAS Registry Number.

49609-84-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Alfa Aesar

  • (A11048)  2-Chloronicotinoyl chloride, 98+%   

  • 49609-84-9

  • 5g

  • 962.0CNY

  • Detail
  • Alfa Aesar

  • (A11048)  2-Chloronicotinoyl chloride, 98+%   

  • 49609-84-9

  • 25g

  • 3425.0CNY

  • Detail
  • Alfa Aesar

  • (A11048)  2-Chloronicotinoyl chloride, 98+%   

  • 49609-84-9

  • 100g

  • 12070.0CNY

  • Detail
  • Aldrich

  • (458821)  2-Chloropyridine-3-carbonyl chloride  98%

  • 49609-84-9

  • 458821-5G

  • 751.14CNY

  • Detail
  • Aldrich

  • (458821)  2-Chloropyridine-3-carbonyl chloride  98%

  • 49609-84-9

  • 458821-25G

  • CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name 2-Chloronicotinyl chloride

1.2 Other means of identification

Product number -
Other names 2-Chloropyridine-3-carbonyl Chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:49609-84-9 SDS

49609-84-9Relevant articles and documents

Substituted-nicotinyl thiourea derivatives bearing pyrimidine moiety: Synthesis and biological evaluation

Ke, Shaoyong,Cao, Xiufang

, p. 627 - 633 (2011)

A series of substituted-nicotinyl thiourea derivatives containing pyrimidine ring were synthesized in good to excellent yield using PEG-400 as solid-liquid phase transfer catalyst under ultrasonic irradiation. The structures of all newly synthesized compounds were elucidated and confirmed by IR, 1H NMR and elemental analysis. The preliminary biological tests show that some of the target compounds present good inhibitory activities against the root and stalk of dicotyledon plants and are safe for monocotyledon plants.

NAD(P+/NAD(P)H models. 83. Molecular asymmetry with a carbonyl group: Electronically controlled stereochemistry in the reaction of NAD(P)+/NAD(P)H analogs


, p. 8133 - 8137 (1994)

The N-methylpyridinium salt of 6,7-dihydro-6-methyl-5-oxopyridino[3,2-d]-2-benzazepin has been synthesized. The salt has axial chirality with respect to the orientation of the carbonyl dipole. An enantiomer of the cation has been obtained as the iodide sa

Synthesis and process optimization of Boscalid by catalyst Pd-PEPPSI-IPrDtBu-An

Xu, Jian,Lan, Xiao-Bing,Xia, Lin-Jian,Yang, Yi,Cao, Gao

, p. 247 - 256 (2021/05/06)

The purpose of this research was to reduce the amount of noble metal palladium catalyst and improve the catalytic performance in the Suzuki–Miyaura cross-coupling reaction, which is the key step in the synthesis of Boscalid. Taking o-bromonitrobenzene and p-chlorophenylboronic acid as raw materials, three kinds of Pd-PEPPSI-IPr catalysts were synthesized and employed in the Suzuki reaction, and then the biaryl product was subjected to reduction and condensation reaction to give Boscalid. Under the optimal reaction conditions, the result showed that the catalytic system exhibits highest catalytic efficiency under aerobic conditions, giving the 2-(4-chlorophenyl)nitrobenzene in over 99 % yield. Moreover, the Pd-PEPPSI-IPrDtBu-An catalyst was minimized to 0.01 mol%. The synthesis process was mild, the post-treatment was simple, and the production cost was reduced, which makes it suitable for industrial production.

New green technology for preparation of 2-chloronicotinic acid


Paragraph 0026; 0028; 0030; 0032, (2019/01/24)

The invention relates to a new green technology for preparation of 2-chloronicotinic acid. The technology includes: adopting nicotinic acid (I) as the raw material, conducting hydrogen peroxide N-oxidation under the action of a catalyst in a water system to obtain nicotinic acid N-oxide (II), then under the action of organic base, conducting phosphorus oxychloride chlorination to synthesize 2-chloronicotinyl chloride (III), and then performing hydrolysis and refining to obtain 2-chloronicotinic acid (IV). The method avoids the use of benzene and acetic acid, has the advantages of short process, safety and environmental protection, good product quality and high yield, is an environment-friendly green synthetic route, and is suitable for industrial production.

A fluorine-containing thiazole aromatic amide compound and use thereof


Paragraph 0020; 0021, (2018/03/26)

The invention discloses a thiazole fluoride-containing aromatic amide compound, which has a structure as shown in the general formula I in the description, wherein R is shown in the description. The compound shown in the general formula I has excellent st

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