6,7-DIACETOXY-4-CHLORO-QUINAZOLINE

Base Information

• Chemical Name: 6,7-DIACETOXY-4-CHLORO-QUINAZOLINE
• CAS No.: 938185-04-7
• Molecular Formula: C12H9ClN2O4
• Molecular Weight: 280.667
• Hs Code.: 2933990090
• Mol file: 938185-04-7.mol

Synonyms:6,7-DIACETOXY-4-CHLORO-QUINAZOLINE;Acetic acid 6-acetoxy-4-chloro-quinazolin-7-yl ester;4-Chloroquinazoline-6,7-diyl diacetate

Chemical Property of 6,7-DIACETOXY-4-CHLORO-QUINAZOLINE

Chemical Property:

• Vapor Pressure: 9.66E-08mmHg at 25°C
• Boiling Point: 434.2°C at 760 mmHg
• PKA: 0.07±0.70(Predicted)
• Flash Point: 216.4°C
• PSA: 78.38000
• Density: 1.423g/cm³
• LogP: 2.13380

Purity/Quality:

97% ^*data from raw suppliers

4-Chloroquinazoline-6,7-diyldiacetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7-DIACETOXY-4-CHLORO-QUINAZOLINE

There total 4 articles about 6,7-DIACETOXY-4-CHLORO-QUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.3%

6,7-diacetoxy-4(3H)-quinazolinone (765249-38-5) → (7-acetoxy-4-chloro-quinazolin-6-yl) acetate (938185-04-7)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-aniline; Inert atmosphere; Reflux;

Reference yield:

3H-6,7-dimethoxyquinazolin-4-one (13794-72-4) → (7-acetoxy-4-chloro-quinazolin-6-yl) acetate (938185-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide; acetic anhydride

2: pyridine

3: trichlorophosphate / chloroform

With pyridine; hydrogen bromide; acetic anhydride; trichlorophosphate; In chloroform;

DOI:10.1021/acsmedchemlett.5b00286

Reference yield:

6,7-dihydroxyquinazolin-4(3H)-one (16064-15-6) → (7-acetoxy-4-chloro-quinazolin-6-yl) acetate (938185-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: trichlorophosphate / chloroform

With pyridine; trichlorophosphate; In chloroform;

DOI:10.1021/acsmedchemlett.5b00286

upstream raw materials:

6,7-diacetoxy-4(3H)-quinazolinone

3H-6,7-dimethoxyquinazolin-4-one

6,7-dihydroxyquinazolin-4(3H)-one

methyl 2-amino-4,5-dimethoxybenzoate

Downstream raw materials:

N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride

N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine