N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride

Base Information

• Chemical Name: N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride
• CAS No.: 938185-05-8
• Molecular Formula: C₂₀H₁₅N₃O₄*ClH
• Molecular Weight: 397.818
• Mol file: 938185-05-8.mol

Synonyms:N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride

Chemical Property of N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride

There total 4 articles about N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(7-acetoxy-4-chloro-quinazolin-6-yl) acetate (938185-04-7) + 3-acetylenephenylamine (54060-30-9) → N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride (938185-05-8)

Guidance literature:

Heating / reflux;

Reference yield:

3H-6,7-dimethoxyquinazolin-4-one (13794-72-4) → N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride (938185-05-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen bromide / 12 h / 100 °C

1.2: pH 8

2.1: pyridine / 2 h / 120 °C

3.1: oxalyl dichloride / chloroform / 0 - 20 °C / Reflux

3.2: Saturated solution

4.1: chloroform / Reflux

With oxalyl dichloride; hydrogen bromide; pyridine; In chloroform;

Reference yield:

6,7-dihydroxyquinazolin-4(3H)-one (16064-15-6) → N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride (938185-05-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 2 h / 120 °C

2.1: oxalyl dichloride / chloroform / 0 - 20 °C / Reflux

2.2: Saturated solution

3.1: chloroform / Reflux

With oxalyl dichloride; pyridine; In chloroform;

upstream raw materials:

(7-acetoxy-4-chloro-quinazolin-6-yl) acetate

3-acetylenephenylamine

6,7-diacetoxy-4(3H)-quinazolinone

6,7-dihydroxyquinazolin-4(3H)-one

Downstream raw materials:

N-(3-ethynylphenyl)-6,7-dihydroxy-4-quinazolinamine hydrochloride

N-(3-ethynylphenyl)-6,7-bis(2-(methoxy-d3)ethoxy-d4)quinazolin-4-amine

N-(3-ethynylphenyl)-6,7-dihydroxy-4-quinazolinamine