2-Chloroamphetamine

Base Information

• Chemical Name: 2-Chloroamphetamine
• CAS No.: 21193-23-7
• Molecular Formula: C9H12ClN
• Molecular Weight: 169.654
• Hs Code.: 2921499090
• UNII: 00Q9Z0HNOQ
• DSSTox Substance ID: DTXSID40943523
• Nikkaji Number: J565.895K
• Wikidata: Q27231371
• Mol file: 21193-23-7.mol

Synonyms:2-chloroamphetamine;2-chloroamphetamine hydrochloride;2-chloroamphetamine hydrochloride, (+-)-isomer;2-chloroamphetamine, (+-)-isomer;o-chloroamphetamine;ortho-chloroamphetamine

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Chemical Property of 2-Chloroamphetamine

Chemical Property:

• Vapor Pressure: 0.0307mmHg at 25°C
• Boiling Point: 244.2°Cat760mmHg
• Flash Point: 117°C
• PSA: 26.02000
• Density: 1.096g/cm³
• LogP: 2.93000
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 169.0658271
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1Cl)N

Technology Process of 2-Chloroamphetamine

There total 4 articles about 2-Chloroamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-chlorophenyl)acetyl chloride (51512-09-5) → 2-Chloro-Amphetamine (21193-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methyl zinc iodide

2: anschliessend mit Natronlauge

With methylzinc iodide;

DOI:10.1021/ja01271a045

Reference yield:

→ 2-Chloro-Amphetamine (21193-23-7)

Guidance literature:

With ethanol; ammonia; at 160 ℃;

DOI:10.1021/ja01210a032

Reference yield:

2-chlorophenylacetone (6305-95-9) + formamide (77287-34-4,77287-35-5,60100-09-6) → 2-Chloro-Amphetamine (21193-23-7)

Guidance literature:

anschliessend mit Natronlauge;

DOI:10.1021/ja01271a045

upstream raw materials:

2-chlorophenylacetone

formamide

2-(2-chlorophenyl)acetyl chloride

Downstream raw materials:

(S)-2-amino-1-(2-chloro-phenyl)-propane

(S)-2-benzamino-1-(2-chloro-phenyl)-propane

(S)-N-(1-phenylprop-2-yl)benzamide

dexamfetamine