Ribavirin IMpurity F

Base Information

• Chemical Name: Ribavirin IMpurity F
• CAS No.: 58151-87-4
• Molecular Formula: C10H14N4O6
• Molecular Weight: 286.24
• Mol file: 58151-87-4.mol

Synonyms:1-(5-O-Acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxaMide;5'-O-Acetyl Ribavirin;Ribavirin IMpurity F

Chemical Property of Ribavirin IMpurity F

Chemical Property:

• Boiling Point: 596.8±60.0 °C(Predicted)
• PKA: 12.89±0.70(Predicted)
• PSA: 149.79000
• Density: 1.84±0.1 g/cm3(Predicted)
• LogP: -1.74040
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), water (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

5’-O-AcetylRibavirin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5’-O-Acetyl Ribavirin is an impurity of Ribavirin (R414475). Ribavirin impurity F.

Technology Process of Ribavirin IMpurity F

There total 2 articles about Ribavirin IMpurity F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2',3',5'-Tri-O-acetyl-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (40372-03-0) → 5'-O-acetylribavirin (58151-87-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; at 20 ℃; for 16h; regioselective reaction; Mechanism;

DOI:10.1002/ejoc.201400085

Reference yield:

→ 5'-O-acetylribavirin (58151-87-4)

Guidance literature:

entspr. 2.3-Isopropylidengeschuetzten Verb., Ac2O;

upstream raw materials:

2',3',5'-Tri-O-acetyl-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

Refernces

• 1、 -. "1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters". . . Retrieved 2008/06/13.