1-[(AMMONIOOXY)METHYL]-2-FLUOROBENZENE CHLORIDE

Base Information

• Chemical Name: 1-[(AMMONIOOXY)METHYL]-2-FLUOROBENZENE CHLORIDE
• CAS No.: 215599-91-0
• Molecular Formula: C7H9ClFNO
• Molecular Weight: 177.6
• Hs Code.: 2922199090
• Mol file: 215599-91-0.mol

Synonyms:1-[(AMINOOXY)METHYL]-2-FLUOROBENZENE HYDROCHLORIDE;1-[(AMMONIOOXY)METHYL]-2-FLUOROBENZENE CHLORIDE;O-(2-FLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE

Chemical Property of 1-[(AMMONIOOXY)METHYL]-2-FLUOROBENZENE CHLORIDE

Chemical Property:

• Melting Point: 180-185°C
• PSA: 35.25000
• LogP: 2.71830

Purity/Quality:

97% ^*data from raw suppliers

O-(2-Fluorobenzyl)hydroxylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(AMMONIOOXY)METHYL]-2-FLUOROBENZENE CHLORIDE

There total 7 articles about 1-[(AMMONIOOXY)METHYL]-2-FLUOROBENZENE CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

O-(o-fluorobenzyl)-2-butanone oxime → O-(2-fluorobenzyl)hydroxylamine hydrochloride (215599-91-0)

Guidance literature:

With hydrogenchloride; In methanol; water; at 37 ℃; for 3.5h;

Reference yield: 82.0%

1-(2-fluorobenzyloxy)-3,4-diphenyl-1H-pyrrole-2,5-dione → 2,3-diphenylmaleic anhydride (4808-48-4) + O-(2-fluorobenzyl)hydroxylamine hydrochloride (215599-91-0)

Guidance literature:

1-(2-fluorobenzyloxy)-3,4-diphenyl-1H-pyrrole-2,5-dione; With potassium hydroxide; In ethanol; water; at 102 ℃; for 0.0833333h; Microwave irradiation; Green chemistry;

With hydrogenchloride; In ethanol; water; pH=4; Temperature; Green chemistry;

DOI:10.1039/c6gc01318j

Reference yield: 60.5%

C9H10FNO2 → O-(2-fluorobenzyl)hydroxylamine hydrochloride (215599-91-0)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 65 ℃;

DOI:10.1016/j.bioorg.2019.103150

upstream raw materials:

2-(2-fluorobenzyloxy) isoindoline-1,3-dione

2-fluorobenzyl alcohol

O-(2-fluorobenzyl)hydroxylamine

o-fluorobenzyl bromide

Downstream raw materials:

3,5-dibromo-2-(2,6-dinitro-4-(trifluoromethyl)phenoxy)benzaldehyde O-(2-fluorobenzyl) oxime

2-(2,6-dinitro-4-(trifluoromethyl)phenoxy)benzaldehyde O-(2-fluorobenzyl) oxime

5-chloro-2-(2,6-dinitro-4-(trifluoromethyl)phenoxy)benzaldehyde O-(2-fluorobenzyl) oxime

5-bromo-2-(2,6-dinitro-4-(trifluoromethyl)phenoxy)benzaldehyde O-(2-fluorobenzyl) oxime