3-(4-Bromophenyl)-6-methylpyridazine

Base Information

• Chemical Name: 3-(4-Bromophenyl)-6-methylpyridazine
• CAS No.: 100677-88-1
• Molecular Formula: C11H9BrN2
• Molecular Weight: 249.11
• Mol file: 100677-88-1.mol

Synonyms:3-(4-Bromophenyl)-6-methylpyridazine

Chemical Property of 3-(4-Bromophenyl)-6-methylpyridazine

Chemical Property:

• PSA: 25.78000
• LogP: 3.21450

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Bromophenyl)-6-methylpyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Bromophenyl)-6-methylpyridazine

There total 3 articles about 3-(4-Bromophenyl)-6-methylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4'-bromophenyl)-pentane-1,4-dione (2108-56-7) → 3-(4-bromophenyl)-6-methylpyridazine (100677-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 48 h / 25 °C

2: chloranil / acetonitrile / 6 h / 20 °C

With chloranil; hydrazine hydrate; In ethanol; acetonitrile;

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) → 3-(4-bromophenyl)-6-methylpyridazine (100677-88-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / ethanol / 24 h / 25 °C

2: hydrazine hydrate / ethanol / 48 h / 25 °C

3: chloranil / acetonitrile / 6 h / 20 °C

With chloranil; potassium carbonate; hydrazine hydrate; In ethanol; acetonitrile;

Reference yield:

2-Methoxypropene (116-11-0) + N'-(2-bromo-1-(4-bromophenyl)ethylidene)-4-methylbenzenesulfonohydrazide (100677-63-2) → 3-(4-bromophenyl)-6-methylpyridazine (100677-88-1)

Guidance literature:

With sodium ethanolate; sodium carbonate; Yield given. Multistep reaction; 1) THF, 2) EtOH, 60 deg C, 18 h;

upstream raw materials:

2-Methoxypropene

N'-(2-bromo-1-(4-bromophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

1-(4'-bromophenyl)-pentane-1,4-dione

para-bromophenacyl bromide

Refernces

• 1、 Clarke, Simon J.,Gilchrist, Thomas L.. "1,4,5,6-Tetrahydropyridazines by Cycloaddition of Enol Ethers to Azoalkenes and their Aromatisation to Pyridazines.". . p. 3371 - 3389. Retrieved 2007/10/02.