Ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-3-yl)acetate

Base Information

• Chemical Name: Ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-3-yl)acetate
• CAS No.: 1256337-01-5
• Molecular Formula: C14H20N2O4
• Molecular Weight: 280.32
• Mol file: 1256337-01-5.mol

Synonyms:Ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-3-yl)acetate

Chemical Property of Ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-3-yl)acetate

Chemical Property:

• PSA: 77.52000
• LogP: 2.60720

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-(6-((tert-butoxycarbonyl)amino)pyridin-3-yl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-3-yl)acetate

There total 7 articles about Ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl carbazate (4248-19-5) + ethyl (6-chloro-pyridin-3-yl)acetate (197376-47-9) → ethyl (6-tert-butoxycarbonylaminopyridin-3-yl)acetate (1256337-01-5)

Guidance literature:

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; for 20h; Heating; Inert atmosphere; Reflux;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + ethyl 2-(6-aminopyridin-3-yl)acetate (1174229-72-1) → ethyl (6-tert-butoxycarbonylaminopyridin-3-yl)acetate (1256337-01-5)

Guidance literature:

With triethylamine; In tert-butyl alcohol; at 50 ℃; for 3h;

Reference yield:

(6-chloro-pyridin-3-yl)-acetonitrile (39891-09-3) → ethyl (6-tert-butoxycarbonylaminopyridin-3-yl)acetate (1256337-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / water / 5 h / Reflux

1.2: 20 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 20 h / Heating; Inert atmosphere; Reflux

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; water;

upstream raw materials:

tert-butyl carbazate

ethyl (6-chloro-pyridin-3-yl)acetate

5-bromo2-nitropyridine

1-(tert-butyl) 3-ethyl 2-(6-nitropyridin-3-yl)malonate

Downstream raw materials:

(6-tert-butoxycarbonylaminopyridin-3-yl) acetic acid

tert-butyl (5-(2-hydroxyethyl)pyridin-2-yl)carbamate