(E)-4-[1-[[4-[2-(DiMethylaMino)ethoxy]phenyl]phenylMethylene]propyl]phenol

Base Information

• Chemical Name: (E)-4-[1-[[4-[2-(DiMethylaMino)ethoxy]phenyl]phenylMethylene]propyl]phenol
• CAS No.: 82413-21-6
• Molecular Formula: C₂₆H₂₉NO₂
• Molecular Weight: 387.522
• Mol file: 82413-21-6.mol

Synonyms:(E)-4-[1-[[4-[2-(DiMethylaMino)ethoxy]phenyl]phenylMethylene]propyl]phenol;4-[(1E)-1-[[4-[2-(DiMethylaMino)ethoxy]phenyl]phenylMethylene]propyl]phenol

Chemical Property of (E)-4-[1-[[4-[2-(DiMethylaMino)ethoxy]phenyl]phenylMethylene]propyl]phenol

Chemical Property:

• PSA: 32.70000
• LogP: 5.70170

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

(E)-4’-HydroxyTamoxifen ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (E)-4’-Hydroxy Tamoxifen is an active metabolite of Tamoxifen (T006000).

Technology Process of (E)-4-[1-[[4-[2-(DiMethylaMino)ethoxy]phenyl]phenylMethylene]propyl]phenol

There total 5 articles about (E)-4-[1-[[4-[2-(DiMethylaMino)ethoxy]phenyl]phenylMethylene]propyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxyphenyl)acetophenone (24845-40-7) → 4-{1-[1-[4-(2-Dimethylamino-ethoxy)-phenyl]-1-phenyl-meth-(E)-ylidene]-propyl}-phenol (82413-21-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 2.) DMF

2: 82 percent / 48percent aq. HBr, acetic acid / 4 h / Heating

3: 98percent H₂SO₄ / 12 h / Ambient temperature

4: 1.) C₂H₅MgBr, 3.) HCl

With hydrogenchloride; sulfuric acid; ethylmagnesium bromide; hydrogen bromide; sodium hydride; acetic acid;

DOI:10.1021/jm00351a010

Reference yield:

4-bromo-phenol (106-41-2) → 4-{1-[1-[4-(2-Dimethylamino-ethoxy)-phenyl]-1-phenyl-meth-(E)-ylidene]-propyl}-phenol (82413-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaH, DMF / 3 h / 85 - 90 °C

2: 1.) C₂H₅MgBr, 3.) HCl

With hydrogenchloride; ethylmagnesium bromide; sodium hydride; N,N-dimethyl-formamide;

DOI:10.1021/jm00351a010

Reference yield:

2-(p-methoxyphenyl)-1-phenylbutan-1-one (35258-39-0) → 4-{1-[1-[4-(2-Dimethylamino-ethoxy)-phenyl]-1-phenyl-meth-(E)-ylidene]-propyl}-phenol (82413-21-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / 48percent aq. HBr, acetic acid / 4 h / Heating

2: 98percent H₂SO₄ / 12 h / Ambient temperature

3: 1.) C₂H₅MgBr, 3.) HCl

With hydrogenchloride; sulfuric acid; ethylmagnesium bromide; hydrogen bromide; acetic acid;

DOI:10.1021/jm00351a010

upstream raw materials:

[2-(4-bromophenoxy)ethyl]dimethylamine

1-Phenyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one

2-(4-methoxyphenyl)acetophenone

4-bromo-phenol

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