Losartan N1-Glucuronide

Base Information

• Chemical Name: Losartan N1-Glucuronide
• CAS No.: 138584-34-6
• Molecular Formula: C₂₈H₃₁ClN₆O₇
• Molecular Weight: 599.043
• Mol file: 138584-34-6.mol

Synonyms:Losartan N1-Glucuronide;1-[5-[4'-[[2-Butyl-4-chloro-5-(hydroxyMethyl)-1H-iMidazol-1-yl]Methyl][1,1'-biphenyl]-2-yl]-1H-tetrazol-1-yl]-1-deoxy-β-D-Glucopyranuronic Acid

Chemical Property of Losartan N1-Glucuronide

Chemical Property:

• Boiling Point: 911.5±75.0 °C(Predicted)
• PKA: 2?+-.0.70(Predicted)
• PSA: 188.87000
• Density: 1.58±0.1 g/cm3(Predicted)
• LogP: 1.80490
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Losartan N1-Glucuronide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Losartan (L470500).

Technology Process of Losartan N1-Glucuronide

There total 2 articles about Losartan N1-Glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lorsartan (114798-26-4) → losartan N1-glucuronide (138584-34-6) + losartan N2-glucuronide (138584-35-7)

Guidance literature:

With phosphate buffer; recombinant human UDP-glucuronosyltransferase 1A₁; In dimethyl sulfoxide; at 37 ℃; for 4h; pH=7.4; Further Variations:; Catalysts; Enzyme kinetics;

DOI:10.1016/j.bcp.2008.07.006

Reference yield:

lorsartan (114798-26-4) → losartan N1-glucuronide (138584-34-6) + losartan O-glucuronide (138613-25-9) + losartan N2-glucuronide (138584-35-7)

Guidance literature:

With human liver microsomes; In dimethyl sulfoxide; at 37 ℃; for 4h; pH=7.4; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1016/j.bcp.2008.07.006

upstream raw materials:

lorsartan

Refernces