Technology Process of 2-Carboxy-3-chloro-5-cyanopyridine, 6-Carboxy-5-chloropyridine-3-carbonitrile, 3-Chloro-5-cyanopicolinic acid
There total 8 articles about 2-Carboxy-3-chloro-5-cyanopyridine, 6-Carboxy-5-chloropyridine-3-carbonitrile, 3-Chloro-5-cyanopicolinic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 3-chloro-5-cyanopicolinate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
With
hydrogenchloride; methanol;
In
dichloromethane;
- Guidance literature:
-
C7H5ClN2O3;
With
oxalyl dichloride; N,N-dimethyl-formamide;
for 1.5h;
Cooling with ice;
With
sodium hydroxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; water / ethanol / 14.5 h / 60 °C
2.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.5 h / 65 °C / Cooling with ice
3.1: water; ammonia / 2 h / 20 °C
3.2: Cooling with ice
4.1: N,N-dimethyl-formamide; oxalyl dichloride / 1.5 h / Cooling with ice
With
hydrogenchloride; thionyl chloride; oxalyl dichloride; ammonia; water; N,N-dimethyl-formamide;
In
ethanol; dichloromethane;
