(S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide

Base Information

Chemical Name:(S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide
CAS No.:1200494-62-7
Molecular Formula:C₁₈H₁₃ClFN₅OS
Molecular Weight:401.852
Hs Code.:

Synonyms:(S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide

Suppliers and Price of (S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide

There total 11 articles about (S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1200497-81-9
3-chloro-5-cyano-pyridine-2-carboxylic acid

: 1301740-74-8
C₁₁H₁₂FN₃S

: 1200494-62-7
(S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide

Guidance literature:: With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; at 0 ℃; for 1h;
DOI:10.1021/acs.jmedchem.0c01917

Reference yield:

: 1311387-86-6
(S)-2-(2-fluoro-5-nitrophenyl)-4,4-dimethoxybutan-2-amine

: 1200494-62-7
(S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetone / 0.5 h / 0 °C

1.2: 40 °C

2.1: acetic acid; iron / water / 1 h / 50 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrogenchloride / methanol; water / 1 h / 0 °C

With hydrogenchloride; iron; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; acetone;
DOI:10.1021/acs.jmedchem.0c01917

Reference yield:

: 1200496-60-1
C₂₅H₂₁FN₂O₅

: 1200494-62-7
(S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Amberlite / methanol / 2.5 h / Reflux

2.1: piperidine / N,N-dimethyl-formamide / 1.17 h / 20 °C

3.1: acetone / 0.5 h / 0 °C

3.2: 40 °C

4.1: acetic acid; iron / water / 1 h / 50 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrogenchloride / methanol; water / 1 h / 0 °C

With piperidine; hydrogenchloride; iron; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/acs.jmedchem.0c01917