2-(3-Hydroxy-2-phenylpropyl)-5-Methoxyphenol

Base Information

• Chemical Name: 2-(3-Hydroxy-2-phenylpropyl)-5-Methoxyphenol
• CAS No.: 152955-28-7
• Molecular Formula: C₁₆H₁₈O₃
• Molecular Weight: 258.317
• Hs Code.: 2909500000
• Mol file: 152955-28-7.mol

Synonyms:2-(3-Hydroxy-2-phenylpropyl)-5-Methoxyphenol

Chemical Property of 2-(3-Hydroxy-2-phenylpropyl)-5-Methoxyphenol

Chemical Property:

• PSA: 49.69000
• LogP: 2.71940

Purity/Quality:

≥99% ^*data from raw suppliers

2-(3-Hydroxy-2-phenylpropyl)-5-methoxyphenol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-Hydroxy-2-phenylpropyl)-5-Methoxyphenol

There total 8 articles about 2-(3-Hydroxy-2-phenylpropyl)-5-Methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenyl-3-(4-methoxy-2-O-methoxymethylphenyl)-1-propanol (152955-24-3) → 3-(2-hydroxy-4-methoxyphenyl)-2-phenyl-1-propanol (152955-28-7)

Guidance literature:

With hydrogenchloride; In methanol; Heating;

Reference yield:

4-methoxy-2-methoxymethoxy benzaldehyde (124555-63-1) → 3-(2-hydroxy-4-methoxyphenyl)-2-phenyl-1-propanol (152955-28-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / NaBH₄ / tetrahydrofuran; ethanol / 0.75 h / Ambient temperature

2: 70 percent / LiBr, 2,6-lutidine, methanesulfonic anhydride / tetrahydrofuran / 30 h / Ambient temperature

3: 45 percent / n-BuLi, isopropylcyclohexylamine, HMPA / tetrahydrofuran; hexane / 0.25 h / -78 °C

4: 50 percent / LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

5: 3 N HCl / methanol / 1 h / Heating

With 2,6-dimethylpyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; N-cyclohexylisopropylamine; lithium bromide; Methanesulfonic anhydride; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane;

DOI:10.3987/com-98-8149

Reference yield:

methyl 2-phenyl-3-(4-methoxy-2-O-methoxymethylphenyl)propanoate (152955-19-6) → 3-(2-hydroxy-4-methoxyphenyl)-2-phenyl-1-propanol (152955-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

2: 3 N HCl / methanol / 1 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; In methanol; diethyl ether;

DOI:10.3987/com-98-8149

upstream raw materials:

2-phenyl-3-(4-methoxy-2-O-methoxymethylphenyl)-1-propanol

2-Hydroxy-4-methoxybenzaldehyde

4-methoxy-2-methoxymethoxy benzaldehyde

2-(methoxymethoxy)-4-methoxybenzyl alcohol

Downstream raw materials:

7-Methoxyisoflavan