4-Methoxy-2-(MethoxyMethoxy)benzaldehyde

Base Information

• Chemical Name: 4-Methoxy-2-(MethoxyMethoxy)benzaldehyde
• CAS No.: 124555-63-1
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Hs Code.: 2912499000
• Mol file: 124555-63-1.mol

Synonyms:Benzaldehyde,4-methoxy-2-(methoxymethoxy);4-methoxy-2-O-methoxymethylbenzaldehyde;2-(O-methoxymethylenoxy)-4-methoxybenzaldehyde;2-(methoxymethoxy)-4-methoxybenzaldehyde;2-O-methoxymethyl-4-methoxybenzaldehyde;4-methoxy-2-methoxymethoxy benzaldehyde;

Chemical Property of 4-Methoxy-2-(MethoxyMethoxy)benzaldehyde

Chemical Property:

• Melting Point: 62-62.5 °C
• Boiling Point: 126-127 °C(Press: 0.05 Torr)
• PSA: 44.76000
• Density: 1.140±0.06 g/cm3(Predicted)
• LogP: 1.49040

Purity/Quality:

99%, ^*data from raw suppliers

4-Methoxy-2-(methoxymethoxy)benzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methoxy-2-(MethoxyMethoxy)benzaldehyde

There total 3 articles about 4-Methoxy-2-(MethoxyMethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + chloromethyl methyl ether (107-30-2) → 4-methoxy-2-methoxymethoxy benzaldehyde (124555-63-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4020(99)00679-1

Reference yield:

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + chloromethyl methyl ether (107-30-2) + N-ethyl-N,N-diisopropylamine (7087-68-5) → 4-methoxy-2-methoxymethoxy benzaldehyde (124555-63-1)

Guidance literature:

In dichloromethane; water;

Reference yield:

2,4-Dihydroxybenzaldehyde (95-01-2) → 4-methoxy-2-methoxymethoxy benzaldehyde (124555-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / K₂CO₃ / acetone / 2 h / Heating

2: 79 percent / KOH / dibenzo-18-crown-6 / acetonitrile / 6 h / Ambient temperature

With potassium hydroxide; potassium carbonate; dibenzo-18-crown-6; In acetone; acetonitrile;

upstream raw materials:

2-Hydroxy-4-methoxybenzaldehyde

chloromethyl methyl ether

2,4-Dihydroxybenzaldehyde

N-ethyl-N,N-diisopropylamine

Downstream raw materials:

2'-Hydroxy-4-methoxy-2,4',6'-tri(methoxymethoxy)chalcone

2-(methoxymethoxy)-4-methoxybenzyl alcohol

(E)-3-(4-Methoxy-2-methoxymethoxy-phenyl)-1-(4-methoxy-phenyl)-propenone

1-(3,4-dimethoxyphenyl)-3-(4-methoxy-2-methoxymethoxyphenyl)-2-propen-1-one