2-Amino-5-chloro-4-fluoro-benzoic acid

Base Information

• Chemical Name: 2-Amino-5-chloro-4-fluoro-benzoic acid
• CAS No.: 351367-77-6
• Molecular Formula: C7H5ClFNO2
• Molecular Weight: 189.574
• Hs Code.: 2922498590
• Mol file: 351367-77-6.mol

Synonyms:2-Amino-5-chloro-4-fluoro-benzoic acid;BENZOIC ACID, 2-AMINO-5-CHLORO-4-FLUORO-

Chemical Property of 2-Amino-5-chloro-4-fluoro-benzoic acid

Chemical Property:

• Boiling Point: 350.3±42.0 °C(Predicted)
• PKA: 4.51±0.10(Predicted)
• PSA: 63.32000
• Density: 1.574±0.06 g/cm3(Predicted)
• LogP: 2.34070
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly, Sonicated), DMSO (Slightly)

Purity/Quality:

≥95% ^*data from raw suppliers

2-Amino-5-chloro-4-fluoro-benzoicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-chloro-4-fluoro-benzoic acid

There total 1 articles about 2-Amino-5-chloro-4-fluoro-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-fluoroanthranilic acid (446-32-2) → 2-amino-5-chloro-4-fluorobenzoic acid (351367-77-6)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 50 ℃; for 5h;

Reference yield: 86.5%

2-amino-5-chloro-4-fluorobenzoic acid (351367-77-6) → 5-chloro-4-fluoro-2-hydrazinylbenzoic acid hydrochloride

Guidance literature:

2-amino-5-chloro-4-fluorobenzoic acid; With hydrogenchloride; sodium nitrite; In water; at 5 ℃; for 0.5h;

With tin(II) chloride dihdyrate; In water; at 5 - 20 ℃; for 20h;

Reference yield: 45.0%

2-amino-5-chloro-4-fluorobenzoic acid (351367-77-6) → (2-amino-5-chloro-4-fluorophenyl)methanol

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 - 50 ℃; for 19h;

upstream raw materials:

4-fluoroanthranilic acid

Refernces

• 1、 -. "QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS". Paragraph 0465; 0466. . Retrieved 2016/11/14.
• 2、 -. "HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE". Page/Page column 122. . Retrieved 2010/06/11.