446-32-2

Basic information

• Product Name: 2-Amino-4-fluorobenzoic acid
• Synonyms: TIMTEC-BB SBB006590;BUTTPARK 15\04-96;2-AMINO-4-FLUOROBENZOIC ACID;4-FLUOROANTHRANILIC ACID;2-Amino-4-FluorobenzoicAcid99%;2-Amino-4-Fluorobenzoic Acid 99%;2-Amino-4-fluorobenzoic;2-Amino-4-fluorobenzoicacid97%
• CAS NO: 446-32-2
• Molecular Formula: C₇H₆FNO₂
• Molecular Weight: 155.13
• EINECS: 207-163-9
• Product Categories: Fluorin-contained Benzoic acid series;Amines and Anilines;Amino Acids and Derivatives;Carboxylic Acids;Phenyls & Phenyl-Het;Benzoic acid;Chemical Amines;Amines;Aromatics;Carboxylic Acids;Phenyls & Phenyl-Het;Benzoic acid series;Fluorine series
• Mol File: 446-32-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 192-196 °C(lit.)
• Boiling Point: 223.67°C (rough estimate)
• Flash Point: 146.2 °C
• Appearance: white to light yellow crystal powder
• Density: 1.3021 (estimate)
• Vapor Pressure: 0.331mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 4.88±0.10(Predicted)
• BRN: 2803665
• CAS DataBase Reference: 2-Amino-4-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-fluorobenzoic acid(446-32-2)
• EPA Substance Registry System: 2-Amino-4-fluorobenzoic acid(446-32-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 446-32-2(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluoroanthranilic Acid (cas# 446-32-2) is a compound useful in organic synthesis.

InChI:InChI=1/C6H3F2NO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H

Upstream product

• 324-03-8 6-fluoroisatin 
• 394-27-4 2-acetamido-4-fluorobenzoic acid 
• 394-01-4 4-fluoro-2-nitrobenzoic acid 
• 459-56-3 4-fluorobenzylic alcohol 
• 60-00-4 ethylenediaminetetraacetic acid 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 1863-63-4 ammonium benzoate 
• 2475-81-2 methyl 4-fluoroanthranilate 
• 119-32-4 4-Methyl-3-nitroanilin 
• 350-78-7 (2E)-N-(3-fluorophenyl)-2-hydroxyiminoacetamide 
• 366-49-4 5’-fluoro-2’-methylacetanilide 
• 367-29-3 3-fluoro-6-methylaniline 
• 446-10-6 2-nitro-4-fluorotoluene 
• 106754-80-7 4-fluoro-2-nitrobenzamide 

Downstream Products

• 321-50-6 7-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione 
• 117324-05-7 2-amino-4-fluoro-benzoic acid ethyl ester 
• 81223-46-3 4-fluoro-2-mercaptobenzyl alcohol 
• 81223-47-4 2-(5-chloro-2-thienylthio)-4-fluorobenzyl alcohol 
• 81223-48-5 2-(5-chloro-2-thienylthio)-4-fluorobenzyl chloride 
• 345-29-9 4-fluorosalicylic acid 
• 56096-93-6 2-(4-Chlorphenylthio)-4-fluorbenzylalkohol 
• 56096-95-8 2-(4-Chlorphenylthio)-4-fluorbenzylchlorid 
• 56096-91-4 2-(4-chlorophenylthio)-4-fluorobenzoic acid 
• 56096-97-0 [2-(4-Chloro-phenylsulfanyl)-4-fluoro-phenyl]-acetonitrile 
• 56096-99-2 <2-(4-chlorophenylthio)-4-fluorophenyl>acetic acid 
• 16499-57-3 7-fluoro-3H-quinazolin-4-one 
• 59-31-4 2-quinolone 
• 917343-25-0 2-amino-4-fluoro-N-methylbenzamide 

Relevant articles and documents

Preparation method of 2-amino-4-fluorobenzoic acid

The invention relates to a preparation method of 2-amino-4-fluorobenzoic acid, which comprises the following steps: by taking cheap and easily available 4-fluorobenzyl alcohol as a raw material, firstly carrying out nitration reaction to obtain a nitro substitute, then carrying out oxidation reaction on the nitro substitute to obtain benzoic acid oxide, and finally carrying out reduction reaction on the benzoic acid oxide to finally obtain 2-amino-4-fluorobenzoic acid which is high in purity and high in yield. The preparation method disclosed by the invention has the characteristics of cheap and easily available raw materials, short reaction route, conventional reaction, mild reaction conditions, high yield and easiness in industrial production.

Selenium-catalyzed intramolecular atom- And redox-economical transformation ofo-nitrotoluenes into anthranilic acids

Anthranilic acids (AAs) are significant basic chemicals used in pharmaceuticals, agrochemicals, dyes, fragrances,etc. Superfluous steps are always involved in obtaining AAs. Herein, we demonstrate a straightforward strategy to transform abundanto-nitrotoluenes into biologically and pharmaceutically significant AAs without any extra reductants, oxidants and protecting groups. Various sensitive groups, such as halogens, sulfide, aldehyde, pyridines, quinolines,etc., can be tolerated in this transformation. A hundred-gram-scale operation is realized efficiently with almost quantitative selenium recycling. Further mechanistic studies and DFT calculations disclosed the proposed atom-exchange processes and the key roles of the selenium species.

ARYLQUINAZOLINES

The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation.