2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-3-METHYLPENTANOIC ACID

Base Information

• Chemical Name: 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-3-METHYLPENTANOIC ACID
• CAS No.: 19506-84-4
• Molecular Formula: C14H15 N O4
• Molecular Weight: 261.277
• Hs Code.: 2925190090
• Mol file: 19506-84-4.mol

Synonyms:2-Isoindolineaceticacid, a-sec-butyl-1,3-dioxo- (6CI,8CI)

Chemical Property of 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-3-METHYLPENTANOIC ACID

Chemical Property:

• Vapor Pressure: 4.95E-08mmHg at 25°C
• Boiling Point: 426.4°Cat760mmHg
• PKA: 3.66±0.22(Predicted)
• Flash Point: 211.7°C
• PSA: 74.68000
• Density: g/cm³
• LogP: 1.71980

Purity/Quality:

97% ^*data from raw suppliers

2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-3-METHYLPENTANOIC ACID ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-3-METHYLPENTANOIC ACID

There total 2 articles about 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-3-METHYLPENTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phthalic anhydride (85-44-9) + isoleucine (319-78-8,443-79-8,1509-34-8,1509-35-9,3107-04-8,7004-09-3,73-32-5,959215-79-3,18875-42-8) → 1,3-dihydro-1,3-dioxo-α-CH(C2H5)(CH3)-2H-isoindole-acetic acid (19506-84-4)

Guidance literature:

at 185 - 190 ℃; for 0.5h;

DOI:10.2147/DDDT.S297013

Reference yield:

phthalic anhydride (85-44-9) + DL-isoleucine (73-32-5,319-78-8,443-79-8,1509-34-8,1509-35-9,3107-04-8,7004-09-3,959215-79-3,18875-42-8) → N,N-phthaloyl-DL-isoleucine (19506-84-4,21844-63-3,29588-88-3,114926-62-4)

Guidance literature:

at 180 - 185 ℃;

DOI:10.1021/ja01184a051

Reference yield: 84.0%

1,3-dihydro-1,3-dioxo-α-CH(C2H5)(CH3)-2H-isoindole-acetic acid (19506-84-4) + phenylboronic acid (98-80-6) → C34H33BN2O8

Guidance literature:

In benzene; for 12h; Reflux;

DOI:10.1515/MGMC.2011.011

upstream raw materials:

phthalic anhydride

DL-isoleucine

isoleucine

Downstream raw materials:

carbon dioxide