4-(4-FLUOROPHENYL)-1,4-DIHYDRO[1,3,5]TRIAZINO[1,2-A][1,3]BENZIMIDAZOL-2-AMINE

Base Information

• Chemical Name: 4-(4-FLUOROPHENYL)-1,4-DIHYDRO[1,3,5]TRIAZINO[1,2-A][1,3]BENZIMIDAZOL-2-AMINE
• CAS No.: 305852-99-7
• Molecular Formula: C15H12FN5
• Molecular Weight: 281.29
• Hs Code.: 2933299090
• Mol file: 305852-99-7.mol

Synonyms:ASISCHEM C37994;AKOS BBS-00005566;4-(4-FLUOROPHENYL)-1,4-DIHYDRO[1,3,5]TRIAZINO[1,2-A][1,3]BENZIMIDAZOL-2-AMINE;1,3,5-TRIAZINO[1,2-A]BENZIMIDAZOL-2-AMINE, 4-(4-FLUOROPHENYL)-1,4-DIHYDRO-;4-(4-FLUOROPHENYL)-1,4-DIHYDRO-1,3,5-TRIAZINO[1,2-A]BENZIMIDAZOL-2-AMINE;TIMTEC-BB SBB013295;[4-(4-fluorophenyl)-4,10-dihydro-[1,3,5]triazino[6,5-b]benzimidazol-2-yl]amine;4-(4-fluorophenyl)-4,10-dihydro-[1,3,5]triazino[6,5-b]benzimidazol-2-amine

Chemical Property of 4-(4-FLUOROPHENYL)-1,4-DIHYDRO[1,3,5]TRIAZINO[1,2-A][1,3]BENZIMIDAZOL-2-AMINE

Chemical Property:

• Boiling Point: 460.6±55.0 °C(Predicted)
• PKA: 7.22±0.40(Predicted)
• PSA: 68.23000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 2.73640

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-Fluorophenyl)-1,4-dihydro[1,3,5]triazino-[1,2-a]benzimidazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-FLUOROPHENYL)-1,4-DIHYDRO[1,3,5]TRIAZINO[1,2-A][1,3]BENZIMIDAZOL-2-AMINE

There total 2 articles about 4-(4-FLUOROPHENYL)-1,4-DIHYDRO[1,3,5]TRIAZINO[1,2-A][1,3]BENZIMIDAZOL-2-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-guanidinobenzimidazole (5418-95-1) + 4-fluorobenzaldehyde (459-57-4) → 2-amino-4-(4'-fluorophenyl)-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazole (305852-99-7)

Guidance literature:

With piperidine; In ethanol; for 2h; Heating;

DOI:10.1016/j.jfluchem.2005.02.009

Reference yield:

1,2-diamino-benzene (95-54-5) → 2-amino-4-(4'-fluorophenyl)-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazole (305852-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / piperidine / ethanol / 2 h / Heating

With piperidine; In ethanol;

DOI:10.1016/j.jfluchem.2005.02.009

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C15H12FN5 (305852-99-7) + phenethylamine (64-04-0) → 6-(4-fluorophenyl)-2-(2-phenylethyl)-2,3,4,6-tetrahydro-1H-[1,3,5]-triazino[1',2':3,4][1,3,5]triazino[1,2-a]benzimidazole (810628-22-9)

Guidance literature:

In 1,4-dioxane; N,N-dimethyl-formamide; for 0.5h; Reflux;

DOI:10.1134/S1070428011070177

upstream raw materials:

2-guanidinobenzimidazole

4-fluorobenzaldehyde

1,2-diamino-benzene

Downstream raw materials:

2-amino-4-(4'-fluorophenyl)-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazole hydrochloride

6-(4-fluorophenyl)-2-(2-phenylethyl)-2,3,4,6-tetrahydro-1H-[1,3,5]-triazino[1',2':3,4][1,3,5]triazino[1,2-a]benzimidazole