Methaqualone

Base Information

• Chemical Name: Methaqualone
• CAS No.: 93240-42-7
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.3
• Mol file: 93240-42-7.mol

Synonyms:2-Methyl-3-o-tolyl-4(3H)-chinazolinon [german]

Chemical Property of Methaqualone

Chemical Property:

• Vapor Pressure: 7.86E-07mmHg at 25°C
• Boiling Point: 406.9°C at 760 mmHg
• Flash Point: 199.9°C
• Density: 1.16g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methaqualone

There total 13 articles about Methaqualone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

dihydroxy-methyl-borane (13061-96-6) + (P)-3-(2-Bromophenyl)-2-methylquinazolin-4(3H)-one → (+)-methaqualone (72-44-6,81718-89-0,81882-39-5,93240-42-7) + (-)-methaqualone (72-44-6,81718-89-0,81882-39-5,93240-42-7)

Guidance literature:

With potassium phosphate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; at 45 ℃; for 22h;

DOI:10.1021/acs.orglett.6b02865

Reference yield: 40.0%

dihydroxy-methyl-borane (13061-96-6) + (P)-3-(2-Bromophenyl)-2-methylquinazolin-4(3H)-one → (+)-methaqualone (72-44-6,81718-89-0,81882-39-5,93240-42-7) + (-)-methaqualone (72-44-6,81718-89-0,81882-39-5,93240-42-7)

Guidance literature:

With potassium phosphate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; at 45 ℃; for 22h;

DOI:10.1021/acs.orglett.6b02865

Reference yield:

2,6-dibromoaniline (608-30-0) → (+)-methaqualone (72-44-6,81718-89-0,81882-39-5,93240-42-7) + (-)-methaqualone (72-44-6,81718-89-0,81882-39-5,93240-42-7)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus trichloride / toluene / 20 h / 80 - 120 °C / Inert atmosphere

2: palladium diacetate; sodium tetrahydroborate; (R)-DTBM-SEGPHOS / N,N-dimethyl-formamide / 21 h / 0 °C / Inert atmosphere

3: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; potassium phosphate / 1,4-dioxane / 22 h / 45 °C

With sodium tetrahydroborate; potassium phosphate; 1,3-bis-(diphenylphosphino)propane; (R)-DTBM-SEGPHOS; palladium diacetate; phosphorus trichloride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/acs.orglett.6b02865

upstream raw materials:

methaqualone

2,6-dibromoaniline

o-acetylamino-benzoic acid

dihydroxy-methyl-borane

Downstream raw materials:

(-)-methaqualone