(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

Base Information

• Chemical Name: (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride
• CAS No.: 1204818-19-8
• Molecular Formula: C10H11ClF3NO2
• Molecular Weight: 269.651
• Hs Code.: 2922499990
• Mol file: 1204818-19-8.mol

Synonyms:Sitagliptin-2;Sitalettinic acid;Sitagliptin Impurity 17;Sitagliptin Impurity 25 HCl;Sitagliptin Acid (USP IMP A);Sitagliptin Acid Impurity HCl;Sitagliptin FP Impurity E Hydrochloride;(R)-b-Amino-2,4,5-trifluoro-benzenebutanoic acid HCl;(R)-b-Amino-2,4,5-trifluoro-benzenebutanoic acid hydrochloride;(βR)-β-Amino-2,4,5-trifluorobenzenebutanoic Acid Hydrochloride

Chemical Property of (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

Chemical Property:

• Melting Point: 218-220℃
• PSA: 63.32000
• LogP: 2.95070
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Air Sensitive

Purity/Quality:

99%, ^*data from raw suppliers

(R)-b-Amino-2,4,5-trifluoro-benzenebutanoicacidhydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

There total 13 articles about (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid (936630-57-8) → (R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride (1204818-19-8,1217809-78-3)

Guidance literature:

With hydrogenchloride; In ethanol; optical yield given as %ee;

DOI:10.1039/b920731g

Reference yield: 87.1%

(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester (1151240-91-3) → (R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride (1204818-19-8,1217809-78-3)

Guidance literature:

(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid ethyl ester; With sodium hydroxide; In methanol; water; at 40 ℃; for 2h;

In methanol; water; pH=3;

Reference yield: 82.8%

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid (486460-00-8,922178-94-7) → (R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride (1204818-19-8,1217809-78-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4h;

upstream raw materials:

(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid

(R)-methyl-3-N-acetylamino-4-(2,4,5-trifluorophenyl)butanoate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

(2,4,5-trifluorophenyl)acetic acid

Downstream raw materials:

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Refernces

• 1、 -. "PROCESS FOR PREPARING R-BETA-AMINO PHENYLBUTYRIC ACID DERIVATIVES". Page/Page column 5. . Retrieved 2011/06/23.
• 2、 Tasnadi, Gabor,Forro, Enik,Fueloep, Ferenc. "Improved enzymatic syntheses of valuable β-arylalkyl-β-amino acid enantiomers". experimental part. p. 793 - 799. Retrieved 2010/06/20.